International Epi Databases to Evaluate AIDS (IEDEA) in central Africa (Region 9)

描述(由申请人提供)：本申请建议建立一个国际流行病学数据库，以评估艾滋病(IEDEA)区域中心，以协调区域9-中部非洲的艾滋病毒数据和数据收集。一个由国际研究三角组织(RTI)、北卡罗来纳州三角研究园支持的地区数据中心将设在刚果民主共和国金沙萨的北卡罗来纳大学/刚果(金)大学公共卫生学院艾滋病毒/艾滋病临床研究部。这一多步骤的研究和能力建设进程将通过扩大/加强北卡罗来纳大学公共卫生学院、金沙萨公共卫生学院、RTI和刚果民主共和国国家多部门中心(PNMLS)之间的现有伙伴关系来开展。其他国际合作者包括：(1)比利时安特卫普热带医学研究所；(2)法国巴黎Mortalite Sante流行病学和人口与发展研究所；(3)法国蒙彼利埃大学发展与国际卫生系研究所。来自布隆迪、喀麦隆、中非共和国、刚果/布拉柴维尔、刚果民主共和国和卢旺达的第9区合作者包括艾滋病毒/艾滋病临床医生/护理提供者、国家艾滋病毒项目代表和国家医学院的教职员工。我们的区域联盟目前在数据库中有20,200名接受抗逆转录病毒治疗的患者，并正在跟踪另外46,000名尚未有资格接受抗逆转录病毒治疗的艾滋病毒感染者。统一我们区域的数据是最初的目标。当这一点到位时，我们提议的研究议程将包括：(1)确定新的适合地区的艾滋病毒护理模式和监测其有效性的系统；(2)监测抗逆转录病毒药物耐药性的哨兵人口；(3)确定该地区艾滋病毒基因多样性的高比率对抗逆转录病毒药物耐药性的作用。

DESCRIPTION (provided by applicant): This application proposes to establish an International Epidemiologic Database to Evaluate AIDS (IEDEA) Regional Center to harmonize HIV data and data collection in Region 9 - Central Africa. A Regional Data Center, backstopped by Research Triangle International (RTI), Research Triangle Park, North Carolina will be located in Kinshasa, Democratic Republic of Congo (DRC) at the University of North Carolina/DRC UNC/DRC) HIV/AIDS Clinical Research Unit at the Kinshasa School of Public Health. This multi-step research and capacity building process will occur through regional expansion/reinforcement of the existing partnership between the UNC's School of Public Health, the Kinshasa School of Public Health, RTI and the DR Congo's Programme National Multisectoriel de Lutte centre le SIDA (PNMLS). Additional international collaborators are: (1) Institute of Tropical Medicine in Antwerp, Belgium; (2) Institut National d'Etudes Demographiques Research Unites Mortalite Sante Epidemiologie et Population and Developpement, Paris, France; (3) Institut de Recherche pour le Developpement and Department of International Health, University of Montpellier, Montpellier France. Region 9 collaborators from Burundi, Cameroon, Central African Republic, Congo/Brazzaville, Democratic Republic of Congo, and Rwanda include HIV/AIDS clinicians /care providers, representatives of national HIV programs, and faculty from national medical schools. Our regional consortium has 20,200 patients currently on ARV's in a database and are following an additional 46,000 HIV-infected individuals who are not yet eligible to receive ART treatment. Harmonization of data across our region is the initial goal. When this is in place, our proposed research agenda will include: (1) Identify new region-appropriate models of HIV care and systems for monitoring its efficacy; (2) Monitor sentinel populations for ARV resistance; (3) Determine the role the high rate of genetic diversity for HIV seen in this region plays on ARV resistance.