Risk factors for Kaposi's sarcoma among HIV-positive individuals in a case control study in Cameroon.
Risk factors for Kaposi's sarcoma among HIV-positive individuals in a case control study in Cameroon.
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DOI：
10.1016/j.canep.2014.02.006
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发表时间：
2014-04
影响因子：
2.6
通讯作者：
Smith, Jennifer S.
中科院分区：
文献类型：
--
作者：
Stolka, Kristen;Ndom, Paul;Hemingway-Foday, Jennifer;Iriondo-Perez, Jeniffer;Miley, Wendell;Labo, Nazzarena;Stella, Jennifer;Abassora, Mahamat;Woelk, Godfrey;Ryder, Robin;Whitby, Denise;Smith, Jennifer S.
关键词：
合并感染卡波西肉瘤疱疹病毒（KSHV）和人类免疫缺陷病毒（HIV）的个体患卡波西肉瘤（KS）的风险大大增加。目前分析的目的是确定艾滋病毒阳性个体中KS的风险辅助因素。我们在喀麦隆对161例HIV阳性和14例HIV阴性病例以及680例HIV阳性和322例HIV阴性对照进行了KS病例对照研究。参与者回答了医生管理的问卷，并提供了血液和唾液标本。通过ELISA测量针对KSHV裂解抗原K8.1和潜伏抗原ORF 73的抗体，以确定KSHV血清状态。进行条件Logistic回归分析，以确定HIV阳性病例和对照组中与KS相关的危险因素的多变量比值比（OR）和95%置信区间（CI）。总体而言，98%（158）的HIV阳性病例、100%（14）的HIV阴性病例、81%（550）的HIV阳性对照和80%（257）的HIV阴性对照为KSHV血清阳性。HIV阳性个体中KS的危险因素包括KSHV血清阳性（OR=9.6; 95% CI 2.9，31.5），未使用蚊帐（OR 1.9; 95% CI 1.2，2.9），少数民族（OR=3.1; 95% CI 1.1，9.3），传统治疗师治疗（OR=2.3; 95% CI 1.5，3.7）、输血史（OR=2.4; 95% CI 1.5，3.9）和癌症家族史（OR=1.9; 95% CI 1.1，3.1）。KSHV血清阳性率≥80%表明喀麦隆一般人群中的流行率较高。在艾滋病毒抗体阳性者中，KS与不使用蚊帐和接受传统治疗者的治疗密切相关，这是令人信服的研究结果，与最近报告的东非数据一致。
Individuals co-infected with Kaposi’s sarcoma herpesvirus (KSHV) and Human Immunodeficiency Virus (HIV) are at greatly increased risk of developing Kaposi’s sarcoma (KS). The objective of the current analysis is to identify risk cofactors, for KS among HIV-positive individuals. We conducted a case-control study of KS in Cameroon on 161 HIV-positive and 14 HIV-negative cases and 680 HIV-positive and 322 HIV-negative controls. Participants answered a physician-administered questionnaire and provided blood and saliva specimens. Antibodies against KSHV lytic, K8.1, and latent, ORF73, antigens were measured by ELISA to determine KSHV serostatus. Conditional logistic regression was performed to determine multivariate odds ratios (OR) and 95% confidence intervals (CI) for risk factors associated with KS among HIV-positive cases and controls. Overall, 98% (158) of HIV-positive cases, 100% (14) of HIV-negative cases, 81% (550) of HIV-positive controls, and 80% (257) of HIV-negative controls were KSHV seropositive. Risk factors for KS among HIV-positive individuals included KSHV seropositivity (OR=9.6; 95% CI 2.9, 31.5), non-use of a mosquito bed net (OR 1.9; 95% CI 1.2, 2.9), minority ethnicity (OR=3.1; 95% CI 1.1, 9.3), treatment from a traditional healer (OR=2.3; 95% CI 1.5, 3.7), history of transfusion (OR=2.4; 95% CI 1.5, 3.9), and family history of cancer (OR=1.9; 95% CI 1.1, 3.1). KSHV seroprevalence of ≥80% indicates a high prevalence in the general population in Cameroon. Among HIV-positive individuals, the strong association of KS with non-use of mosquito nets and treatment from traditional healers are compelling findings, consistent with recently reported data from East Africa.
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