Biomechanical Basis of Mild Traumatic Brain Injury

与运动相关的轻度创伤性脑损伤(MTBI或脑震荡)是一个重要的公共卫生问题 由于这些伤害的发生率较高，相对年轻的被伤者可能较长 长期残疾，反复发生的累积效应的危险，以及无效的战略 预防。我们建议开发和验证一个头部碰撞加速度的量化模型 使新的临床和治疗技术的转化性研究和开发能够减少 MTBI的发生率和不良反应。实验、临床和产品开发项目包括 团队成员将允许针对潜在的病理机制和临床的特定假设驱动的研究 MTBI的后遗症。研究脑震荡的病理机制的关键是获得实际的 头部因撞击而加速和曝光。头部撞击遥测系统(HIT系统)技术 是以前开发和验证的，用于现场测量头部撞击加速度。这 技术将首次使生物力学、临床和临床研究成为可能。 闭合性头部损伤受试者的神经心理学数据，允许直接测量损伤 参数及其临床后果。在一项对大学足球运动员和 男女大学生曲棍球运动员，这项建议的三个具体目标是：1)提高打击率 用于现场头部撞击加速度数据大规模记录、存储和检索的系统，2)量化 使用HIT系统测试对MTBI损伤的冲击耐受性的假设 无论是累积冲击还是性别影响这些容忍度，以及3)与头部撞击加速度相关 使用与MTBI相关的临床变量来检验头部加速度增加会增加的假设 脑震荡运动员脑损伤的短期测量相对于匹配的对照组 副业和临床工具，包括标准化的副业评估、神经心理测试和 功能磁共振成像。这些研究成果将为实现长远发展目标提供科学依据。 并部署新的战略，以改进检测、预防、减少发病率和改善治疗 MTBI。

Sports-related mild traumatic brain injury (MTBI or concussion) is an important public health problem because of the high incidence of these injuries, the relative youth of those being injured with possible long term disability, the danger of cumulative effects from repeat incidences, and ineffective strategies for prevention. We propose to develop and validate a quantitative model of head impact acceleration that enables translational research and development of new clinical and therapeutic techniques to reduce the incidence and negative effects of MTBI. Experimental, clinical and product development projects among team members will allow hypothesis-driven research specific to the underlying pathomechanics and clinical sequelae of MTBI. Crucial to the study of the pathomechanics of concussion is the acquisition of actual head accelerations and exposures due to impact. Head Impact Telemetry System (HIT System) technology was previously developed and validated for measuring head impact accelerations in the field. This technology will, for the first time, enable prospective studies of biomechanical, clinical, and neuropsychological data in human subjects with closed head injury, allowing for direct measurement of injury parameters and their clinical consequences. Within a study population of collegiate football players and male and female collegiate hockey players, the three specific aims of this proposal are: 1) improve HIT system for large-scale recording, storage, and retrieval of on-field head impact acceleration data, 2) quantify head impact acceleration using HIT system to test hypotheses on the impact tolerance to MTBI injury and whether cumulative impacts or gender influence these tolerances, and 3) correlate head impact acceleration with clinical variables related to MTBI to test the hypothesis that increased head acceleration increases short-term measures of brain injury for concussed players relative to matched controls using validated sideline and clinical tools including standardized sideline assessments, neuropsychological testing, and fMRI. The results of these studies will provide the scientific basis for achieving long-term goals to develop and deploy novel strategies to improve detection, prevention, reduce the incidence, and improve treatment of MTBI.