Bayesian Methods for Genomics with Variable Selection

描述（由申请人提供）：本研究提案的总体目标是开发新的贝叶斯方法，用于分析基因组学中出现的数据。特别令人感兴趣的是大量变量可用的情况，并且选择预测子集是目标之一。我们提出的理论发展的动机是各种各样的研究，一些由我们的生物医学合作者，使用DNA微阵列技术进行。该项目的目标之一是在统计学中的变量和特征选择方面贡献新的理论发展。另一个目标是为生物医学界提供用于分析高维数据的合理方法。识别重要的生物标志物将有助于更好地了解特定疾病的分子机制，从而改善诊断、药物开发和患者治疗。我们拟议研究的具体目标是： 1.高维数据的聚类：我们将开发新的贝叶斯方法，用于同时聚类实验单元并识别最能区分不同组的变量。 2.删失生存结局的高维数据分析：我们将研究参数生存模型中变量选择的新方法。该方法将导致估计的生存和识别的预测变量。 3.应用于微阵列研究：我们将应用特定目标#1和#2的方法到一系列涉及微阵列数据的生物医学研究中。这些研究包括对类风湿性关节炎和骨关节炎以及成人急性淋巴细胞白血病的研究。 4.蛋白质组学数据的应用：我们将调整我们的方法来提取蛋白质组学数据中的重要特征的问题，结合降维小波技术。 5.软件开发：我们将开发统计软件，并向公众提供。

DESCRIPTION (provided by applicant): The overall objective of this research proposal is to develop new Bayesian methodologies for the analysis of data that arise in genomics. Of particular interest are situations where a large number of variables is available and selection of a predictive subset is one of the goals. The theoretical developments we propose are motivated by a variety of studies, some conducted by our biomedical collaborators, using DNA microarray technologies. One of the goals of this project is to contribute novel theoretical developments in variable and feature selection in statistics. Another goal is to provide the biomedical community with sound methods for the analysis of high-dimensional data. The identification of important biomarkers will provide a better understanding of the molecular mechanisms involved in specific diseases, and will in turn improve diagnosis, drug development, and treatment of patients.The specific aims of our proposed research are: 1. Clustering of High-Dimensional Data: We will develop novel Bayesian methods for simultaneously clustering experimental units and identifying the variables that best discriminate the different groups. 2. Analysis of High-Dimensional Data with Censored Survival Outcomes: We will investigate novel methods for variable selection in parametric survival models. The methods will lead to estimates of the survival and to the identification of the predictive variables. 3. Application to Microarray Studies: We will apply the methods of Specific Aims #1 and #2 to a series of biomedical studies involving microarray data. These include studies on rheumatoid arthritis and osteoarthritis and adult acute lymphobiastic leukemia. 4. Application to Proteomic Data: We will adapt our methodologies to the problem of extracting important features in proteomics data, incorporating dimension reduction wavelet techniques. 5. Software development: We will develop statistical software and will make it available to the public.