PARKINSON'S DISEASE NEUROPROTECTION CLINICAL TRIALS: CLINICAL CENTER

描述（由申请人提供）：帕金森病（PD）是一种常见的进行性神经退行性疾病。最近的研究已经提出了一些潜在的神经保护剂，但需要一个大的临床试验来确定有效性。这只能由经验丰富的PD试验中心联合完成。本提案的目的是概述我们的经验，兴趣和兴奋，成为一个中心，并愿意与其他网站合作。卡尔加里大学的运动障碍项目是阿尔伯塔南部唯一的PD诊所，为近200万人口提供服务。其主要目的是为帕金森病（PD）患者提供综合临床护理和临床研究。临床医生和护士协调员在合作临床试验方面拥有12年的经验。该诊所因一贯的高招聘和提供高质量的参与而享有国际声誉。其优势之一是将临床护理与临床研究整合在一个单元中。 无论患者是否接受临床护理和/或参与临床试验，患者将经常由同一名神经科医生和护士协调员长期护理。由于以下因素，拟议试验的招募工作将很容易实现：1）大型转诊基础2）该地区没有竞争性PD中心3）建立了包括3000名患者的数据库4）与社区和亚专业神经科医生的合作关系5）与PD非专业组织（包括南阿尔伯塔帕金森病协会）的密切工作关系，加拿大帕金森病协会的诊所网站与卡尔加里大学和非专业组织建立了联系。已确定的患者人群的维护通过组织既定的计划得到加强。1)患者对我们的综合护理计划的忠诚和赞赏2）临床研究和临床计划的整合3）神经科医生和临床护士的参与的连续性4）患者通过电子邮件和电话与诊所成员进行沟通的便利性和规律性。该诊所得到了卡尔加里大学和卡尔加里卫生区的大力支持，以实现其为PD患者提供全面，综合的最先进项目的目标，并推进该领域的研究。

DESCRIPTION (provided by applicant): Parkinson's disease (PD) is a common, progressive, neurodegenerative disorder. Recent studies have suggested a number of potential neuroprotective agents, but a large clinical trial would be needed to determine effectiveness. This could only be accomplished by a consortium of experienced PD trial centers. The aim of this proposal is to outline our experience, interest and excitement in becoming a center, and willingness to cooperate with other sites. The Movement Disorders Program at the University of Calgary is the only PD clinic in Southern Alberta, serving a population of almost 2 million. Its major aim is to provide comprehensive clinical care integrated with clinical research to Parkinson's disease (PD) patients. Clinic physicians and nurse coordinators have a proven track record of 12 years of experience in collaborative clinical trials. The clinic has an international reputation for being consistently a high recruiter, and for providing high quality participation. One of the strengths is the integration of clinical care with clinical research in one unit. Patients will frequently be cared for by the same neurologist and nurse coordinator on a long-term basis, whether they are receiving clinical care and/or participating in clinical trials. Recruitment for the proposed trials will be easily achieved due to the following factors: 1) large referral base 2) no competing PD centres in the area 3) established database including 3000 patients 4) collegial working relationship with community and sub-specialty neurologists 5) close working relationship with PD lay organizations, including Parkinson's Society of Southern Alberta, and Parkinson Society Canada 6) clinic website linked to University of Calgary and lay organizations. Maintenance of the identified patient population is enhanced by the organization of the established program. 1) proven loyalty and appreciation of patients for our comprehensive care program 2) integration of clinical research and clinical programs 3) continuity of involvement of neurologists and nurse clinicians 4) ease and regularity of patient communication with clinic members via e-mail and phone. The clinic has strong support from the University of Calgary and Calgary Health Region to fulfill its aim of providing comprehensive, integrated state of the art programs to PD patients, and advancing research in this area.