Trauma Molecular Pathogenesis and Regeneration Training Grant

描述(申请人提供)：本申请寻求支持在创伤医学领域建立一个新的博士后培训计划。该项目是在损伤的分子发病机制和治疗方面日益增长的跨学科基础、临床和转化研究的推动下开展的，是芝加哥大学组织损伤和修复方面成熟的正式研究生课程(附录I-3)和研究项目的产物。我们的项目增长是由新的分子再生创伤疗法、细胞膜的分子再生和蛋白质结构作为创伤研究方法的研究进展所产生的巨大潜在临床影响推动的，作为创伤研究的一种方法，它始于21年前的芝加哥大学，现在已经得到广泛验证，并成为一个自我维持的研究领域。今天，各种大学和公司都有足够的成熟的衍生研究，足以证明正式的教育计划是合理的。要逆转创伤的后果，需要恢复失去的膜屏障功能，改造天然的大分子结构，控制氧生物化学，核酸修复，以及代谢能电荷的重建。这一新领域的新研究者必须具备细胞生理学、膜生物物理学、蛋白质化学、氧生物化学、核酸修复、动物研究方法、临床研究指南以及分子功能的计算和诊断成像等方面的能力。拟议的培训方案符合这些要求。芝加哥大学生物科学分部是开展此类培训计划的理想地点。首先，该大学拥有完善的、资金充足的研究项目，涵盖了上述所有领域和更多领域。这里的研究工作是跨学科的和综合的，为发现奠定了基础。建议书中详述了许多最先进的核心设施。此外，受训者将获得一台最近由NIH拨款资助的超级计算机，该计算机具有生物医学领域前所未有的能力，可以模拟创伤的分子动力学和合成伴侣的行为，以再生正常的分子结构。此外，我们已经有多年的教学历史，现在需要由培训计划导师共同教授专门专注于细胞损伤的研究生课程。 与公共卫生的相关性：在美国，创伤是导致人类在生命的前40年发病和死亡的主要原因，导致永久性残疾的年轻人人数不断增加。这是一笔巨大的代价。这一独特的培训计划将为内科科学家在了解创伤后受损组织的分子发病机制和分子再生方面的临床或基础/翻译研究生涯做好准备。

DESCRIPTION (provided by applicant): This application seeks support to establish a new post-doctoral training program in the field of trauma medicine. The program is motivated by the growing integrative cross-disciplinary basic, clinical and translational research in the molecular pathogenesis and treatment of injury and is the outgrowth of well-established formal graduate courses(Appendix I-3) and research programs in tissue injury and repair at the University of Chicago. Our programmatic growth is driven by the large potential clinical impact resulting from research advances into new molecular regeneration trauma therapies, Molecular regeneration of cellular membranes and protein structure as an approach to trauma research had its beginnings at the University of Chicago more than 21 years ago and has now widely validated and emerging as a self-sustaining field of research . Today, there is sufficient established derivative research across various universities and companies to justify a formal educational program. Reversing the consequences of trauma requires recovery of the lost barrier function of membranes, reformation of native macromolecular structure, control of oxygen biochemistry, nucleic acid repair, and reestablishment of metabolic energy charge. New investigators in this new field must have competences in cellular physiology, membrane biophysics, protein chemistry, oxygen biochemistry, nucleic acid repair, animal research methods, clinical research guidelines, as well as computational and diagnostic imaging of molecular function. The proposed training program meets these requirements. The University of Chicago's Biological Sciences Division is an ideal site to launch such a training program. First, the University has well established and well funded research programs covering all of the mentioned areas mentioned and more. The research efforts here are interdisciplinary and integrated, setting the stage for discovery. There are many state of the art core facilities that are detailed in the proposal. Moreover, trainees will have access to a recently NIH grant funded super-computer with capabilities unprecedented in biomedicine to model molecular dynamics of trauma and behavior of synthetic chaperones to regenerate normal molecular structure. In addition, we already have in place a multi-year history of teaching now required graduate courses specifically focused on cell injury co-taught by the training program mentors. PUBLIC HEALTH RELEVANCE: In the United States, trauma is the primary cause of human morbidity and mortality in the first four decades of life resulting in an increasing population of young people with permanent disabilities . This comes as an enormous cost. This unique training program will prepare Physician Scientists for clinical or basic/translational research careers in understanding the molecular pathogenesis and molecular regeneration of injured tissue following trauma.