Core C: Translational Research

翻译研究核心设施是专门设计来促进和促进人类的参与 皮肤和皮肤病相关研究的对象。它旨在从人类获取最大限度的信息 通过提供一种资源，将患者队列的组织与使用 组织、结果研究、临床试验和实验室研究。该核心的结构是为了满足 SDRC成员对人体组织的需求（例如打孔活检、角膜刀、吸引水泡），以提供 SDRC成员具有用于人体皮肤研究的使能技术（例如，模拟太阳能 辐射，色度计，经表皮水分流失装置），并导致在开发新的 有利于SDRC成员资格的技术（例如，用于光动力治疗的成像系统，皮肤 超声、体内共焦成像）。它旨在提供一个具有成本效益的中央资源，以确定和 招募志愿者参与人体体内研究和/或捐献血液或皮肤活检组织， 体内/体外研究。核心职能的利用主要是通过与 通过临床和转化科学转介患者和其他研究者的医生 合作，病例综合癌症中心，艾滋病研究中心和其他研究中心 在大学里。一名研究助理负责协调这些服务。核心还旨在提供总体 管理从实验室到床边的新疗法临床试验，重点是 提供最佳的翻译和临床数据。一个在一般试验设计、监管和 人类研究的合规性方面，组装以有效指导或进行高质量的研究， 通过与对皮肤研究感兴趣的各种研究人员的互动。此外， 临床和实验室研究人员被鼓励插入连续的实验室研究，以阐明机制 治疗的作用和疾病的病理机制核心还提供支持、指导和 对SDRC成员进行有关人体研究合规性的教育。

Translational Research Core Facility is specifically designed to promote and facilitate involvement of human subjects for skin and skin disease-related research. It aims to derive maximum information from human studies by providing a resource that integrates organization of patient cohorts with mechanistic studies using tissues, outcomes research, clinical trials, and laboratory investigation. This Core is structured to meet the SDRC membership's needs for human tissue, (e.g. punch biopsies, keratomes, suction blisters), to provide the SDRC membership with enabling technologies for human skin investigation (e.g. simulated solar radiation, chromometer, transepidermal water loss device), and to lead in the development of novel technologies that will benefit SDRC membership (e.g. imaging system for photodynamic therapy, skin ultrasound, in vivo confocal imaging). It aims to provide a cost-efficient, central resource to identify and recruit volunteers to participate in human in vivo studies and/or donate blood or skin biopsy tissue for ex vivo/in vitro investigations. The utilization of core functions is expanded mainly by active interactions with physicians who refer patients and with other investigators through the Clinical and Translational Science Collaborative, Case Comprehensive Cancer Center, Center for Aids Research, and other research foci within the University. A research assistant coordinates these services. The core also aims to provide overall management of clinical trials of novel therapies brought from the laboratory to the bedside with emphasis on providing optimal translational and clinical data. A group with expertise in general trial design, regulatory and compliance aspects of human studies, assemble to efficiently direct or conduct high quality studies that arise through interaction with various investigators interested in skin research. Additionally, interactions between clinical and laboratory researchers are fostered to insert adjunctive laboratory studies to clarify mechanisms of action of therapies and pathomechanisms of disease. The core also provides support, mentoring and education regarding human research compliance, to members of the SDRC.