Renal blood flow, vascular stiffness, and the DASH diet

描述(由申请人提供)： 这次K24奖项的竞争性续签申请是为了在我(保罗·R·康林)进一步开展以患者为导向的研究和指导初级调查人员的工作时提供支持。我的职业生涯一直专注于研究血压调节机制，最近还研究了改善糖尿病护理的方法。我的长期目标仍然是通过临床试验研究改变生活方式的策略，以减少高血压和糖尿病患者的肾脏和心血管疾病风险因素。在目前的获奖期之前和期间，我是三项干预性营养研究的联合调查员，这三项研究探索了大量和微量营养素对血压的影响。作为这些研究的直接延伸，我现在正在调查停止高血压饮食方法(DASH)对肾脏和心血管血流动力学的影响，以更好地了解该饮食降低血压的机制。在这些研究中，我验证了DASH饮食对肾脏血流量、肾脏和血管对血管紧张素II的反应性、血管僵硬和舒张期功能具有ACE抑制物样作用的假设。这些研究是在单纯性收缩期高血压患者中进行的。我还扩大了我的临床研究计划，将我们附属的退伍军人医学中心的资助研究包括在内，在那里我利用信息技术研究护理管理策略，以改善糖尿病患者的血压和血糖控制。由于K24奖项所提供的受保护时间的直接结果，我正在指导3名初级调查人员(其中两人拥有职业发展奖)，他们于2007年初接受了一名新的研究员加入我的行列，我还共同指导了另外两名个人。我在哈佛医学院K30资助的“临床科学学者计划”中担任领导角色，担任指导委员会主席。在新的获奖期内，我将继续我的资助研究计划，并直接或间接地通过K30计划扩大我的指导范围。我热衷于指导初级研究人员，这些人注定要从事以患者为中心的研究，特别是那些对肾脏和心血管生理学、介入性营养或糖尿病护理管理感兴趣的人。在这个奖项的支持下，我将在多个层面上对未来以患者为导向的研究人员产生重大影响。

DESCRIPTION (provided by applicant): This competitive renewal application for a K24 award is to provide support as I (Paul R. Conlin) further my work in patient-oriented research and mentoring of junior investigators. My career has focused on studying mechanisms of blood pressure regulation and more recently, methodologies to improve diabetes care. My long-term goals remain focused on studying lifestyle modification strategies to reduce renal and cardiovascular disease risk factors in patients with hypertension and diabetes through clinical trials. Prior to and during the current award period, I was a co-investigator in three interventional nutrition studies that explored the effects of macro- and micronutrients on blood pressure. As a direct extension of these studies, I am now investigating the effects of the Dietary Approaches to Stop Hypertension (DASH) diet on renal and cardiovascular hemodynamics, to better understand the mechanisms by which the diet lowers blood pressure. In these studies, I am testing the hypothesis that the DASH diet has ACE inhibitor-like effects on renal blood flow, renal and vascular responsiveness to angiotensin II, vascular stiffness, and diastolic function. These studies are being conducted in patients with isolated systolic hypertension. I have also extended my clinical research program to include funded studies at our affiliated VA Medical Center, where I study care management strategies using information technology, to improve blood pressure and glucose control in patients with diabetes mellitus. As a direct result of the protected time afforded by this K24 award, I am mentoring 3 junior investigators (two of whom have career development awards), have accepted a new research fellow to join me in early 2007, and I co-mentor two other individuals. I have assumed a leadership role in the K30-funded "Scholars in Clinical Sciences Program" at Harvard Medical School, serving as Chair of the Mentoring Committee. During the new award period, I will continue with my funded research program and expand the scope of my mentoring, both directly and indirectly through the K30 program. I have a great passion for mentoring junior investigators destined for careers in patient-oriented research, particularly those interested in renal and cardiovascular physiology, interventional nutrition or diabetes care management. With the support of this award, I will make a significant impact on future patient-oriented researchers at multiple levels.