ANIMAL CORE

(一)目标 动物核心将为调查人员提供怀孕和非怀孕的慢性仪器 绵羊和非器皿怀孕和未怀孕的动物。动物核心的具体目标是： (A)在怀孕75天时获得有时间日期的怀孕动物。这些动物将被随机分配到 在80和81个同性恋者怀孕时接受赋形剂或倍他米松注射，(B)长期准备 用于不同研究项目的仪器化成年羊或胎羊；(C)进行尸检和便利 为个别项目中描述的体外研究收集组织；(D)促进体内研究 急、慢性条件下胎儿、妊娠和非妊娠绵羊生理变量监测研究 条件。

(1) Objective The Animal Core will provide the investigators with chronically instrumented pregnant and nonpregnant sheep and with non instrumented pregnant and nonpregnant animals. The specific goals of the Animal Core are: (a) to obtain time-dated pregnant animals at 75 days of gestation. These animals will be randomly assigned to receive either vehicle or betamethasone injections at 80 an 81 gays gestation, (b) to prepare chronically instrumented adult or fetal sheep for use in the different research projects, (c) to conduct necropsies and facilitate the collection of tissues for the in vitro studies described in the individual projects, (d) to facilitate the in vivo studies involving monitoring physiologic variables in fetal, pregnant and nonpregnant sheep under acute or chronic conditions.