FASEB SRC on Lipid Droplets: Metabolic Consequences of the Storage of Neutral Lip

描述（由申请人提供）：肥胖症和相关病理（如胰岛素抵抗、糖尿病和心血管疾病）的流行促使对储存在细胞内脂滴（LD）中的中性脂质的生物学和代谢的研究激增。阐明脂滴的生物发生、储存、运输、脂解和氧化等基本过程对于设计新的治疗方法至关重要。 代谢紊乱的治疗策略。本次会议的脂滴：中性脂质储存的代谢后果将汇集来自众多学科的科学家，以定义，描述和分析关键的科学问题和细胞生物学，生物化学和脂滴生理学的最新进展。关于这一主题的首次会议于2007年举行，2010年的第二次会议受到了极大的热情。从那时起，脂滴领域呈指数级增长，到2011年11月PubMed搜索“脂滴”检索到2021篇已发表论文的程度。拟议的会议将汇集从事脂滴生理学和代谢的各种不同方面的科学家，目的是促进新的假设，方法和合作。许多在这个新兴领域，以前没有参加过相同的会议，小型会议的形式和隐蔽的会议地点将促进一个亲密和互动的环境中，初级研究人员，包括研究生，博士后研究员和初级教师，将有充分的机会与更高级的既定研究人员进行互动。本申请要求资助10名研究生、博士后研究员和初级研究人员参加将于2012年7月22日至27日在科罗拉多斯诺马斯举行的会议。该格式将包括开幕之夜的主旨演讲，八个会议的会谈邀请发言者，并从提交的摘要中选择几个额外的简短的谈话。会议主题包括：1）脂滴的结构和行程，2）脂滴细胞生物学中的新途径，3）中性脂质合成的机制，4）脂质的递送和代谢，5）对脂滴在代谢中的调节和作用的新见解， 6)脂滴运输和周转，7）脂滴在全身代谢和疾病状态中的组织特异性作用，和8）脂滴的病理作用。两个为期2天的海报会议，以及从摘要中选择的简短演讲，将允许更多的研究人员，包括研究生和博士后研究员，介绍他们的研究。 公共卫生相关性：这次会议将汇集脂质生物化学，细胞生物学和生物生理学的专家，从蠕虫和昆虫到小鼠和人类，讨论脂滴的生物学。脂肪细胞、肝脏、肌肉和心脏等组织中脂滴的发育和利用是治疗这些疾病的关键过程， 如肥胖症、2型糖尿病、动脉粥样硬化和代谢综合征。因此，更好地了解脂滴形成，动力学和营业额将提供新的信息，可用于影响这些疾病的发展。

DESCRIPTION (provided by applicant): The prevalence of obesity and associated pathologies such as insulin resistance, diabetes, and cardiovascular disease has prompted an explosion of research on the biology and metabolism of neutral lipid which are stored within lipid droplets (LD) within cells. The elucidation of fundamental processes such as lipid droplet biogenesis, storage, trafficking, lipolysis, and oxidation is critical in designing new therapeutic strategies for metabolic disorders. This conference on Lipid Droplets: Metabolic Consequences of the Storage of Neutral Lipids will bring together scientists from numerous disciplines for the purpose of defining, describing, and analyzing critical scientific problems and recent advances in the cell biology, biochemistry, and physiology of lipid droplets. The inaugural conference on this topic occurred in 2007 and a second conference in 2010 was met with extreme enthusiasm. Since then, the lipid droplet field has grown exponentially, to the extent that a November 2011 PubMed search for "lipid droplet" retrieved 2021 published papers. The proposed meeting will bring together scientists working on diverse and varied aspects of lipid droplet physiology and metabolism, with the goal of facilitating new hypotheses, approaches, and collaborations. Many in this emerging field, have not previously attended the same conferences, The small conference format and secluded conference site will foster an intimate and interactive environment in which junior investigators, including graduate students, postdoctoral fellows, and junior faculty, will have ample opportunity to interact with more senior established investigators. This application requests funding to support the participation of 10 graduate students, postdoctoral fellows, and junior investigators at the conference to be held July 22-27, 2012 at Snowmass, Colorado. The format will include an opening night Keynote Address, eight sessions of talks with invited speakers, and several additional short talks to be selected from submitted abstracts. The session topics include: 1) The architecture and itinerary of lipid droplets, 2) new pathways in lipid droplet cell biology, 3) mechanisms of neutral lipid synthesis, 4) delivery and metabolism of lipids, 5) new insights into the regulation and role of lipid droplets in metabolism, 6) lipid droplet trafficking and turnover, 7) tissue-specific roles of lipid droplets in systemic metabolism and disease states, and 8) pathologic role of lipid droplets. Two 2-day poster sessions, as well as the short talks to be selected from abstracts, will allow additional investigators, including graduate students and postdoctoral fellows, to present their research. PUBLIC HEALTH RELEVANCE: This conference will bring together experts in lipid biochemistry, cell biology, and physiology of organisms ranging from worms and insects to mouse and man to discuss the biology of lipid droplets. The development and utilization of lipid droplets in tissues such as fat cells, liver, muscle and heart, are key processes in disorders such as obesity, type 2 diabetes, atherosclerosis, and the metabolic syndrome. Thus, a better understanding of lipid droplet formation, dynamics, and turnover will provide new information that may be used to impact the development of these disorders.