ShEEP Request for Assuring Research Reproducibility with an Integrated Sample and Data Management System

在此应用程序中，我们请求购买全面集成的样本和数据管理 系统，包括一台TubeWriter 360打印机和一个FreezerWorks实验室信息管理系统 (LIMS)。这些工具灵活、通用，它们结合在一起将大大提高生产率 以及退伍军人管理局调查人员的研究能力。 这个系统为退伍军人管理局的研究人员提供了几个关键的优势。总体而言，实验室打印机与 具有复杂但灵活和用户友好的LIMS将增强研究的重复性和促进 遵守最佳研究实践的国际标准。这将通过减少错误来实现 与样品贴错标签、实验室工作人员的做法以及试剂或设备的可变性有关，再加上 用于样本和数据以及元数据跟踪的全面系统。TubeWriter 360打印不掉的墨水 各种实验室设备，包括各种大小的塑料和玻璃容器，以及打印1D和 除文本之外的二维条形码。该打印机与FreezerWorks LIMS完全集成，可轻松跟踪 可定制工作流中特定于项目的大量数据和元数据。数以千计的样本将很容易被提取， 在项目的整个生命周期中唯一、正确地标记和跟踪，元数据将链接到 用于元分析和自我审计的分析数据。 基于这些优势，以下退伍军人管理局研究人员和项目将从全面的 集成的样本和数据管理系统，由TubeWriter 360和Freezerworks组成。 1.Edward Janoff，医学博士，首席研究员：CSR&D功勋奖《HIV-1和老龄化对粘膜的影响》 疫苗反应。“ 2.LIron Caplan，医学博士，首席研究员：HSR&D功勋奖：利用人口进行二级事件预防 经皮冠状动脉介入术后风险管理。 3.Robert Keith，医学博士，首席研究员：Blr&D功勋奖：肺癌的PPAR伽玛激动剂 化学预防“ 4.丽莎·布伦纳，博士，当地现场调查员，CSR&D资助--《弓形虫贡地，犬尿氨酸途径， 以及退伍军人的自杀行为“ 5.尼古拉斯·沃尔特，医学博士，首席研究员：CSR&D职业发展奖《血液表达》 作为结核病反应生物标记物的概况“

In this application, we request the purchase of a comprehensive integrated sample and data management system, comprising a TubeWriter 360 printer and a FreezerWorks Laboratory Information Management System (LIMS). These instruments are flexible, versatile, and together they will substantially enhance the productivity and research capabilities of VA investigators. This system provides several key advantages for VA researchers. Overall, a laboratory printer in conjunction with a sophisticated but flexible and user-friendly LIMS will enhance research reproducibility and promote compliance with international standards for best research practices. This will be achieved by reduction in errors related to sample mislabeling, laboratory worker practice, and reagent or equipment variability, coupled with a comprehensive system for sample and data and metadata tracking. The TubeWriter 360 prints indelible ink on a wide variety of laboratory equipment, including plastic and glass containers of many sizes, and prints 1D and 2D barcodes in addition to text. The printer is fully integrated with the FreezerWorks LIMS, which easily tracks myriad data and metadata specific to a project in customizable workflows. Thousands of samples will be easily, uniquely, and correctly labeled and tracked throughout the life of a project, and metadata will be linked with analytical data for meta-analyses and self-audits. Based on these advantages, the following VA researchers and projects will benefit from the comprehensive integrated sample and data management system, comprised of the TubeWriter 360 and Freezerworks. 1. Edward Janoff, MD, Principal Investigator: CSR&D Merit Award “Impact of HIV -1 and Aging on Mucosal Vaccine Responses.” 2. Liron Caplan, MD, Principal Investigator: HSR&D Merit Award “Secondary Event Prevention using Population Risk Management After PCI.” 3. Robert Keith, MD, Principal Investigator: BLR&D Merit Award “PPAR Gamma Agonists for Lung Cancer Chemoprevention” 4. Lisa Brenner, PhD, local site investigator, CSR&D funded – “Toxoplasma Gondi, the Kynurenine Pathway, and Suicidal Behavior in Veterans” 5. Nicholas Walter, MD, PhD, Principal Investigator: CSR&D Career Development Award “Blood Expression Profiles as a Biomarker for Responses to Tuberculosis”