Biodegradable Polymer Surgical Sealant with Increased Adhesion and Reduced Inflammation

项目摘要 本项目的目标是开发一种可喷涂的、可生物降解的聚合物外科密封剂， 手术后并发症的死亡率。目前临床上可用的外科密封剂具有高的 成本高、材料性能差，并且难以精确存款。利用一种叫做溶液吹扫的技术 通过纺丝，我们已经证明了直接存款适形生物可降解聚合物纤维外科手术的能力， 密封剂，用于体内手术部位，具有出色的密封强度。本研究的总体假设 减少炎症和增加聚合物外科密封剂的组织粘附将使我们能够 在临床前试验中证明成功降低肠吻合术后并发症发生率。这 该项目将研究可生物降解聚合物的可喷雾组合，如聚（乳酸-乙醇酸共聚物） 聚乳酸-己内酯共聚物（PLGA）或聚（丙交酯-共-己内酯）、聚（乙二醇）（PEG），以及可以 减少炎症或增加湿组织粘附。本研究的具体目的是：（1） 通过使用嵌段共聚物控制亲水性来减少对可生物降解聚合物的反应的炎症 添加剂(2)评价PLGA-PEG外科封闭剂的体内肠功能和并发症发生率。（三） 使用功能化纳米颗粒增加湿组织粘附力，增加界面处的物理粘合。 这些研究所产生的见解也将适用于其他聚合物生物医学设备，如 缝合线和组织工程支架，增加了工作的重要性。本提议是 旨在补充研究金培训计划，开发跨学科的材料技术技能 科学和生物学，导致生物材料研究的学术职业道路。

Project Summary This project’s objective is to develop a sprayable, biodegradable polymer surgical sealant for decreasing high mortality rate complications that occur after surgery. Surgical sealants currently available in the clinic have high cost, poor material properties, and are difficult to precisely deposit. Utilizing a technique called solution blow spinning, we have demonstrated the ability to directly deposit conformal biodegradable polymer fiber surgical sealants to the site of surgery in vivo with exceptional sealing strength. The overall hypothesis for this research is that reducing inflammation and increasing tissue adhesion of polymer surgical sealants will allow us to demonstrate success in pre-clinical trials for reducing complication rate after an intestinal anastomosis. This project will investigate sprayable combinations of biodegradable polymers such as poly(lactic-co-glycolic acid) (PLGA) or poly(lactide-co-caprolactone), poly(ethylene glycol) (PEG), and functionalized nanoparticles that can reduce inflammation or increase wet tissue adhesion. The Specific Aims of the proposed research are: (1) Reduce inflammation in response to biodegradable polymers by controlling hydrophilicity using block copolymer additives. (2) Evaluate intestinal function and complication rate for PLGA-PEG surgical sealants in vivo. (3) Increase wet tissue adhesion using functionalized nanoparticles that increase physical bonding at the interface. The insights produced by these studies will also be applicable to other polymeric biomedical devices, such as sutures and tissue engineering scaffolds, increasing the significance of the work. This proposal has been designed to complement a fellowship training plan that develops cross-disciplinary technical skills in materials science and biology, leading to an academic career path in biomaterials research.