Development of a Web-Based Group Intervention to Support Ovarian Cancer Survivors

 描述（由申请人提供）：卵巢癌是第二常见的妇科癌症;然而，每年死于卵巢癌的妇女多于死于所有其他妇科部位癌症的妇女。卵巢癌幸存者经常经历高水平的痛苦，睡眠障碍，疲劳，神经病变，多种症状和副作用，以及存在的担忧，沿着一般预后不良。此外，我们还记录了与卵巢癌疾病进展相关的心理社会因素和生理途径之间的密切联系。由于对生活质量（QOL）的许多方面的妥协，加上大多数这些患者的生存率低，开发创新的方法来改善生活质量是至关重要的，但研究卵巢癌幸存者的心理社会干预的潜在疗效是非常有限的。发展亲自干预的障碍包括任何一个地点的卵巢癌幸存者人数少和患者虚弱。基于对卵巢癌幸存者的焦点访谈反馈，我们一直在开发一种针对卵巢癌幸存者的干预措施，借鉴认知行为压力管理（CBSM）和基于正念的减压（MBSR）的关键要素，沿着接受和承诺疗法（ACT）的一些基于价值的内容。在过去的一年里，我们开发了一个移动的响应网络平台，提供基于网络的实时会议心理社会干预，卵巢癌患者可以从家里访问。此应用程序的主要目标是进一步开发、Web部署、现场可用性和现场 在卵巢癌幸存者中测试这种干预措施。这项研究计划的最终目标将是利用网络进行更大规模的随机临床试验。 分娩，检查情绪、症状和QOL沿着临床相关终点和生物标志物。 该应用程序的意义在于，这种干预有可能 改善卵巢癌幸存者的生活质量，并可能有能力延长无复发生存期。

 DESCRIPTION (provided by applicant): Ovarian cancer is the second most common gynecologic cancer; however, more women die annually from ovarian cancer than from cancers of all other gynecologic sites combined. Ovarian cancer survivors often experience high levels of distress, sleep disturbances, fatigue, neuropathies, multiple symptoms and side effects, and existential concerns, along with a generally poor prognosis. Additionally, we have documented strong links between psychosocial factors and physiological pathways related to disease progression in ovarian cancer. Because of compromises to many aspects of quality of life (QOL) combined with low rates of survival for the majority of these patients, development of innovative approaches for improving QOL is of paramount importance, but research examining the potential efficacy of psychosocial interventions in ovarian cancer survivors has been extremely limited. Barriers to development of an in-person intervention have included low populations of ovarian cancer survivors at any one site and debility of patients. Based on focus interview feedback from ovarian cancer survivors, we have been developing an intervention targeted to ovarian cancer survivors, drawing from key elements of Cognitive Behavioral Stress Management (CBSM) and Mindfulness-Based Stress Reduction (MBSR) along with some of the value-based content of Acceptance and Commitment Therapy (ACT). Over the last year we have developed a mobile responsive web platform to deliver a live web-based conferencing psychosocial intervention that ovarian cancer patients can access from their homes. The primary goal of this application is further development, web deployment, field usability, and field testing of this intervention among ovarian cancer survivors. The ultimate goal of this program of research will be to conduct a larger scale randomized clinical trial of this intervention using web delivery, with examination of mood, symptoms, and QOL along with clinically relevant endpoints and biomarkers. The significance of the application is that this intervention has the potential to improve quality of life of ovarian cancer survivors and may have the ability to lengthen the period of recurrence free survival.