CWRU Case Comprehensive Cancer Center NCTN Lead Academic Participating Site

描述（由申请人提供）：本项目是为了支持凯斯西储大学（CWRU）的凯斯综合癌症中心（Case CCC）作为新重组的国家临床试验网络（NCTN）的主要学术参与站点。NCTN是一个由合作团体、学术和社区机构以及国家核心设施组成的国家联盟，与NCI合作进行改变肿瘤学实践的临床试验。这主要是以I期和III期前瞻性多中心试验的形式，以及与这些试验相关的相关科学工作。我们的角色是促进和支持NCTN的使命，以改善癌症患者的结果，通过以下具体目标：1。无论哪个协作组是协调中心，NCTN试验都能以示范性的效率和数据质量积累大量患者。这包括详细的生物标本和癌症成像/技术数据的贡献。在过去的几十年里，我们在前合作社系统内的这一奋进中取得了很大的成功，并将继续并进一步扩大这一生产力。2.领导NCTN合作组及其运营中心，以及与临床试验研究相关的NCI监督和咨询委员会。我们的教职员工已经并将继续担任研究主席，联合主席，翻译研究合作者，委员会成员和共同研究者，在NCTN系统内进行广泛的临床试验研究。3.与NCTN社区的其他成员合作进行创新，基于假设的研究，这将导致实践改变临床试验。这包括从NCTN临床试验中进行生物标本/翻译分析和临床二次分析，以及开发和执行可能导致未来后期NCTN研究的试点研究（后者是通过与Case CCC开发治疗计划和I期临床试验工作（U 01 CA 062502）合作进行的）。

DESCRIPTION (provided by applicant): This project is to support the Case Comprehensive Cancer Center (Case CCC) of Case Western Reserve University (CWRU) as a Lead Academic Participating Site in the newly reorganized National Clinical Trials Network (NCTN). The NCTN is a national consortium of Cooperative Groups, Academic and Community institutions, and National Core Facilities working with the NCI to perform practice-changing clinical trials in oncology. This is primarily in the form of Phase 1 and III prospective multicenter trials, and the correlative scientific work associated with these trials. Our role is to promote and support the mission of the NCTN to improve outcomes for patients with cancer, through the following specific aims: 1. to accrue large numbers of patients to NCTN trials, regardless of which Cooperative Group is the coordinating center, with exemplary efficiency and data quality. This includes contributions of detailed biological specimens and cancer imaging/technical data. We have demonstrated a high level of success in this endeavor over several decades within the former cooperative group system, and will continue and further expand upon this productivity. 2. To provide leadership to the NCTN Cooperative Groups and their operations centers, as well as NCI oversight and advisory committees related to clinical trials research. Our faculty members have been and will continue to serve as study chairs, co-chairs, translational research collaborators, committee members and co-investigators for a broad range of clinical trials research within the NCTN system. 3. To collaborate with other members of the NCTN community on innovative, hypothesis-based research that will lead to practice-changing clinical trials. This includes working on bio specimens/translational analyses and clinical secondary analyses from NCTN clinical trials, as well as developing and performing pilot studies that may lead to future late-stage NCTN research (the latter is via collaboration with the Case CCC Developmental Therapeutics Program and the Phase I clinical trials effort (U01CA062502).