6th ASM Conference on Cell-Cell Communication in Bacteria

项目概要 细菌从定义上讲是单细胞生物，但它们像其他形式的生命一样， 令人惊讶的复杂方法来协调行为。过去25年的研究 揭示了各种细菌可以通过不同的机制进行交流。在大多数情况下 这些微生物的对话是通过交换可扩散的信号发生的， 也是依赖接触的通信的明显例子。许多微生物利用这些 信号机制来监测和应对人口密度，这一过程通常被描述为 作为群体感应。大部分研究都集中在单一物种的交流上， 越来越多的研究领域是多个物种之间更复杂的交流行为 细菌或细菌和其他真核生物。细菌间的交流不是 然而仅限于群体感应机制，越来越多的证据表明， 信令可以在不同容量的范围内起作用。这种沟通具有深刻的 影响了我们对病原体和病原体如何调节关键因素的理解 与其他人和他们的宿主互动。该申请要求财政支持 第六届美国微生物学会主办的细胞-细胞会议 细菌通讯，将于2017年10月16日至19日在佐治亚州雅典举行。有 CCCB会议的两个主要目标。第一是把会议作为一个平台， 促进和吸引年轻和种族多样化的研究人员参与细菌 传播研究年轻而多样化的研究人员将被选为本次会议的发言人。 会议，并指导午餐将为学生提供机会，探索 细菌传播领域的职业选择多样性。第二个目标是 会议旨在促进具有不同专业知识的研究人员之间的互动。因此，小 研究小组将被创建，在午餐期间坐在一起，每个成员 来自不同的研究领域：结构生物学，计算生物学， 生物学、合成生物学、化学、细菌分子遗传学、微生物生态学，以及 微生物致病在这些小组中，科学家们将讨论他们最紧迫的问题， 细菌通讯的研究挑战，目的是创造新的解决方案， 研究思路，甚至未来的合作。

PROJECT SUMARY Bacteria by definition are single-celled organisms, but they, like other forms of life, have evolved surprising complex methods to coordinated behaviors. Research over the past 25 years has revealed that a wide range of bacteria can communicate by diverse mechanisms. In most cases these microbial conversations occur through the exchange of diffusible signals, although there are also clear examples of contact-dependent communication. Many microbes use these signaling mechanisms to monitor and respond to population density, a process often described as quorum sensing. Much of this research has focused on single species communication, but a growing reseach area is the more complex behavior of communication between multiple species of bacteria or bacteria and other eukaryotic organisms. Interbacterial communication is not however restricted to quorum sensing mechanisms and there is mounting evidence that signaling can function in a range of different capacities. This communication has profound impacts on our understanding of how pathogens and commensals often regulate factors critical for interaction with each other and their hosts. This application requests financial support for the sixth American Society for Microbiology-sponsored conference on Cell-cell Communication in Bacteria, to be held from October 16 – 19, 2017, in Athens, GA. There are two main goals of the CCCB conference. The first is to have the meeting serve as a platform to promote and attract young and ethnically diverse investigators involved in bacterial communication research. Young and diverse researchers will be chosen to be speakers at this conference, and a mentoring lunch will provide students with the opportunity to explore the diversity of career options in the bacterial communication field. The second goal of this conference is to foster interactions between reseachers with diverse expertise. Thus, small groups of researchers will be created that are seated together during lunch, with each member of the group coming from from a different research area: structural biology, computational biology, synthetic biology, chemistry, bacterial molecular genetics, microbial ecology, and microbial pathogenesis. In these small groups scientists will discuss their most pressing research challenges in bacterial communication with the goal of creating new solutions, research ideas, and even future collaborations.