Effect of Trauma-Related Stress During Acute Alcohol Intoxication on Driving-Related Risky Decision-Making

7.项目总结/摘要 拟议的项目旨在为PI在学术环境中作为科学家的职业生涯做好准备， 该计划侧重于病因机制，有害的结果，以及之间的共同发生的途径 创伤暴露、创伤后应激和酗酒问题，目的是促进 对发展和背景敏感的共同发展模式，为有效预防、选择性 干预和治疗那些与这些衰弱的条件作斗争。某综合训练 因此，制定了一项计划，以系统地推进PI在以下方面的培训：1）背景相关风险 因素，共病，评估工具，以及与创伤暴露，创伤后 压力和问题酒精使用和2）开发，实施，分析和传播 针对遭受创伤的个人的预防计划。重要的是，拟议的研究旨在 通过帮助PI完善相关的研究技能，通过可行的 结合初级和次级赞助商的强化指导，重点课程，强化 研讨会、非现场培训机会和整个申请中描述的传播活动。 拟议的样本将包括140名创伤暴露的成年饮酒者认可创伤后应激障碍症状。主 研究的目的是测试急性创伤相关压力的诱导（通过脚本驱动的图像）是否 酒精中毒（0.06%BrAC）将影响驾驶相关的风险决策-驾驶意愿， 负面后果的可能性，以及基于绩效的风险任务（通过游戏， 在黄色交通灯变化期间停止车辆）。参与者将被随机分配到 酒精或安慰剂条件，并接受自传体创伤脚本或中性脚本。是 预计（1）酒精+创伤脚本条件（即醉酒和压力）的参与者将 赞同更大的驾驶意愿和更小的负面后果的可能性比那些在 酒精+中性脚本条件（即仅醉酒）和（2）酒精+创伤脚本中的参与者 与所有其他条件相比，驾驶相关风险的增加最大。 拟议的项目与国家酒精滥用和酒精中毒研究所F31机制保持一致， 三种关键方式。首先，该研究项目旨在扩展我们对调节风险因素的理解， 醉酒驾驶的影响，通过检查“真实的时间”创伤相关的压力，在醉酒驾驶- 相关风险决策。其次，调查结果也将为教育和预防工作提供信息 作为“即时”（即生态）干预的信息，最终目标是降低高流行率 醉酒驾驶的概率最后，该项目将作为一个重要的 为PI提供培训机会，在其独立研究计划的开发过程中提供量身定制的培训 以预防性创伤和酗酒工作为目标。

7. Project Summary/Abstract The proposed project aims to prepare the PI for a career as a scientist in an academic setting with a research program focused on etiological mechanisms, deleterious outcomes, and pathways of co-occurrence between trauma exposure, posttraumatic stress, and problematic alcohol use, with the aim of advancing developmentally- and contextually-sensitive models of comorbidity that inform effective prevention, selective intervention, and treatment for those struggling with these debilitating conditions. A comprehensive training plan was therefore constructed to systematically advance the PI’s training in: 1) contextually-relevant risk factors, comorbidity, assessment tools, and sophisticated research related to trauma exposure, posttraumatic stress, and problematic alcohol use and 2) the development, implementation, analysis, and dissemination of prevention programs that target individuals exposed to trauma. Importantly, the proposed study is designed to complement this training program by helping the PI to refine relevant research skills via the feasible combination of intensive mentoring from primary and secondary sponsors, focused coursework, intensive workshops, off-site training opportunities, and dissemination activities described throughout the application. The proposed sample will include 140 trauma-exposed adult drinkers endorsing PTSD symptoms. The primary research goal is to test whether induction of acute trauma-related stress (via script-driven imagery) during alcohol intoxication (.06% BrAC) will influence driving-related risky decision-making – willingness to drive, perceived likelihood of negative consequences, and performance-based risk-tasking (via a game involving stopping a vehicle during a changing yellow traffic light). Participants will be randomly assigned to either an alcohol or placebo condition and to receive either an autobiographical trauma script or neutral script. It is expected that (1) participants in the alcohol + trauma script condition (i.e. intoxicated and stressed) will endorse greater willingness to drive and lesser perceived likelihood of negative consequences than those in the alcohol + neutral script condition (i.e. only intoxicated) and (2) participants in the alcohol + trauma script condition will evidence the greatest increase in driving-related risk-taking compared to all other conditions. The proposed project aligns with the National Institute on Alcohol Abuse and Alcoholism F31 mechanism in three key ways. First, the research project aims to extend our understanding of modulating risk factors for intoxicated driving by examining the influence of “real time” trauma-related stress during intoxication on driving- related risky decision-making. Second, findings will serve to inform educational and prevention efforts, as well as inform “in the moment” (i.e. ecological) intervention, with the ultimate goal of reducing the high prevalence of intoxicated driving among individuals exposed to trauma. Finally, the project will serve as an important training opportunity for the PI through tailored training in the development of his independent research program targeting prevention-oriented trauma and alcohol use work.