Biostatistics Core

项目总结 生物统计核心(BC)的总体目标是提供统计设计和分析专业知识支持 莫菲特癌症中心(MCC)成员的研究努力。服务始于分析设计和 确定样本量(例如，赠款和临床试验提交)，导致项目实施、监测 积累关于正在进行的项目和手稿开发的研究数据。卑诗省提供密钥 定量分析结果，包括表格、数字和科学结论。学院生物统计学家 提供生物统计学方面的教育和培训，积极参加科学审查委员会(SRC) 以及议定书审查和监测委员会(PRMC)，并担任内部赠款申请的审查员。 BC的具体目标是：1)通过提供高质量的生物统计设计和分析来支持成员 服务；2)就生物统计资源和工具对调查人员进行教育和培训；3)开发和 实施最先进的统计分析方法。BC还支持开展研究 通过参与各种监督委员会(例如，SRC和PRMC)。 BC包括9名教员、7名生物统计员、1名核心设施经理和1名项目经理。 学院生物统计学家将他们50%到60%的努力献给了BC，并得到了拨款的支持， 来自临床试验的收入，以及机构支持。工作人员生物统计员和核心设施经理是 致力于BC，并得到按存储容量使用计费、临床试验收入和机构支持的支持。 BC的教职员工参与了科学研究的所有阶段，从研究设计到发表 研究成果。不列颠哥伦比亚省的大部分努力都涉及不列颠哥伦比亚大学的教职员工团队。在过去的资金周期中，BC扮演了 在肺部和皮肤孢子赠与中都有重要作用。此外，不列颠哥伦比亚省的生物统计学家是每个 由研究人员发起的治疗性临床试验在MCC进行。 在过去的五年里，BC支持了500多项临床试验，所有五项研究的研究努力 已获得SRC批准的项目和研究项目。在最近的财政年度，卑诗省 支持78个成员，75%的使用率是由同行评审资助的成员。有两名卑诗省的教职员工 四个SRC和PRMC各自的成员。

PROJECT SUMMARY The overall goal of the Biostatistics Core (BC) is to provide statistical design and analysis expertise supporting the research efforts of Moffitt Cancer Center (MCC) members. Service begins with analytical design and determination of sample size (e.g., grant and clinical trial submissions), leading to project conduct, monitoring of accumulating research data on active projects, and manuscript development. The BC provides key quantitative analytical results, including tables, figures, and scientific conclusions. Faculty biostatisticians provide education and training in biostatistics, participate actively in the Scientific Review Committees (SRC) and Protocol Review & Monitoring Committee (PRMC), and serve as reviewers for internal grant applications. The BC's Specific Aims are to: 1) Support members by providing high-quality biostatistical design and analysis services; 2) Educate and train investigators on biostatistical resources and tools; and 3) Develop and implement methods for state-of-the-art statistical analyses. The BC also supports the conduct of research through involvement on various oversight committees (e.g., SRC and PRMC). The BC includes nine faculty, seven staff biostatisticians, a Core Facility Manager and a Project Manager. Faculty biostatisticians dedicate 50% to 60% of their effort to the BC and are supported by grant funding, revenue from clinical trials, and institutional support. Staff biostatisticians and the Core Facility Manager are dedicated to the BC and are supported by chargebacks, revenue from clinical trials, and institutional support. BC faculty and staff are involved at all stages of scientific research, from study design to publication of research findings. Most BC efforts involve BC faculty-staff teams. During the past funding cycle, the BC played significant roles in both the Lung and Skin SPORE grants. In addition, BC biostatisticians are part of every investigator-initiated therapeutic clinical trial conducted at MCC. Over the past five years, the BC has supported over 500 clinical trials, research efforts across all five research programs, and research projects that have received SRC approval. In the most recent fiscal year, the BC supported 78 members, with 75% of usage for peer-reviewed-funded members. There are two BC faculty members on each of four SRCs and the PRMC.