Impact of P. acnes hyaluronidases on acne pathogenesis

摘要 痤疮是一种重要的人类皮肤病，被认为是由皮肤共生性痤疮引起的。 我们已经鉴定出两种类型的透明质酸酶，由痤疮假单胞菌产生，要么是支持的，要么是反对的 煽动性的。编码促炎症透明质酸酶的痤疮假单胞菌对人类的定植 似乎与中度痤疮的发展有关，相反地，与P. 痤疮编码抗炎的透明质酸酶，与健康的皮肤有关。基于我们的 研究结果表明，透明质酸酶通过影响促炎潜能在痤疮中发挥作用。 痤疮假单胞菌的分离株。对于目标1，我们建议研究两者的致病机制。 小鼠痤疮模型中的透明质酸酶。对于目标2，我们进一步寻求调查这种联系 透明质酸酶类型和引发痤疮的潜力之间的关系 痤疮假单胞菌菌株，来自有或没有痤疮的人。

Abstract Acne is an important human skin disorder and is thought to be caused by skin commensal P. acnes. We have identified two types of hyaluronidases, made by P. acnes, that are either pro or anti- inflammatory. Human colonization by P. acnes that encodes the pro-inflammatory hyaluronidase appears to be associated with development of moderate acne, and conversely colonization with P. acnes that encodes the anti-inflammatory hyaluronidase is associated with healthy skin. Based on our findings, we propose that hyaluronidases play a role in acne by affecting the pro-inflammatory potential of P. acnes strains. For Aim 1, we propose to study the pathogenic mechanisms of both hyaluronidases in murine models of acne. For Aim 2, we further seek to investigate the association between hyaluronidase type and acne-genic potential using one of the best characterized collection of P. acnes strains, from individuals with or without acne.