Developing a novel medical-grade microneedle patch to treat acne vulgaris

帝国生物科学公司的目标是成为第一个进入市场的医疗用微针药物输送产品。微针介导给药是指药物通过皮肤表面的非侵入性给药。这是皮下注射针头的一种替代方法，可以提高患者的依从性。扩展微针贴片技术将成为一种非常有价值的工具，可以轻松地输送各种药物，但不会引起皮肤刺激和副作用。帝国生物科学针对寻常痤疮。本项目旨在了解应用微针技术治疗寻常型痤疮的安全性和有效性，这些类型的痤疮历来被认为对口服药物反应较差和/或有副作用。工作将开发一个强大而稳定的平台，用于将药物分子直接输送到相关皮肤问题产生的皮肤中；为皮肤内细胞类型相互作用的临床前数据提供关键分析，并绘制与人类皮肤炎症性痤疮相关的微针技术的安全性和有效性概况；从而选择临床研究的主要候选药物。

Imperial Bioscience aims to be the first-to-market with their microneedle drug delivery product for medical use. Microneedle-mediated delivery is defined as the non-invasive delivery of medications through the skin surface. This is an alternative to hypodermic needles, which provides enhanced patient compliance. Expanded microneedle patch technology will become a highly valuable tool for delivering various pharmaceuticals with ease but without provoking skin irritation and side effects.Imperial Bioscience targets acne vulgaris. This project aims to understand the safety and efficacy of anti-acne drugs applied with microneedle technology in treating types of acne vulgaris that are historically considered less responsive and/or with side effects to oral medications. Work will develop a robust and stable platform for a novel means for delivering drug molecules directly into the skin where associated skin concerns originated; provide critical analysis of preclinical data for interactions of the cell types within the skin and mapping out safety and efficacy profile of microneedle technology associated with human skin inflammatory disorder of acne; leading to selection of a lead candidate for clinical study.