Mucosal vaccine for influenza on inactivated virus and mannan

流感是一种呼吸系统疾病，在世界范围内导致显著的发病率和死亡率。目前的流感疫苗是由三种目前流通的灭活流感毒株制成的，这些毒株可以诱导抗体反应，从而对抗病毒，从而对抗感染。尽管有疫苗可用，但仍需要新的方法来增加疫苗的活性、使用和分布。为此，正在探索几种基于使用额外试剂来提高免疫原性和无针头递送的方法。我们有一种以糖为基础的天然化合物，可以用来提高人体对癌症和细菌和病毒等传染病的免疫力。当这些制剂被应用到小鼠的鼻孔中时，它们会对肺部、肠道、泪水和唾液中的感染源产生抗体反应，这些抗体可以作为感染源的屏障。我们正在将一种灭活的流感病毒与这种天然糖结合起来，以研究它是否会产生抗体，从而保护小鼠和雪貂免受流感病毒的侵袭。这种方法将首先在人类流感病毒上试验，如果成功，将在禽流感病毒上试验。如果这种制剂能够保护小鼠和雪貂免受人类或禽流感的感染，它可能会发展成为人类预防禽流感的疫苗。由于它可以通过鼻子给药，它将得到广泛使用，在大流行情况下可以在没有合格人员的情况下随时使用。

Influenza is a respiratory disease that causes significant morbidity and mortality worldwide. Current influenza vaccines are a preparation of three currently circulating inactivated influenza strains that induces an antibody response that can combat the virus and therefore infection. Despite the availability of a vaccine new approaches are needed to increase the activity, usage and distribution. To this end several approaches based on using additional agents to increase the immunogenicity and needle free delivery are being explored. We have a natural sugar based compound that can be used to increase the body's immunity to cancers and infectious agents such as bacteria and viruses. When these preparations are applied into the nostril of mice they generate antibody responses to the infectious agent in the lungs, gut, tears, saliva that can act as a barrier to infectious agents. We are incorporating an inactive flu virus with this natural sugar to investigate if it produces antibody that can protect mice and ferrets from the flu virus. This method will be first tried with the human flu virus and if successful will be tried with the bird flu virus. If the preparation can protect mice and ferrets from human or bird flu infection it could develop into a human vaccine against bird flu. Since it can be administered by the nose it will be widely used and can be used readily without qualified personnel in the case of a pandemic.