Testing and forecasting hippocampal theta wave propagation in learning and memory

标题：测试和预测学习和记忆中的海马theta波传播 摘要： 精神疾病状态与严重的认知缺陷有关，这可能会严重损害 独立生活的能力。为了理解和有效地治疗精神健康障碍， 确定支持自适应行为的信息如何在大型网络中传递所必需的 神经细胞的。大脑节律，如局部场电位振荡，已被假设为组织神经 在多个时标上进行电路处理，以协调思想和行动。此外，地球上的异常现象 已经观察到患有精神分裂症、自闭症、双相情感障碍和广泛精神分裂症的人的大脑节律。 一系列其他神经疾病。在受精神疾病影响的神经振荡中， 海马theta节律，这对学习和记忆至关重要，在精神分裂症和 焦虑症。重要的是，已发现theta振荡沿海马区传播。 背腹轴。尽管从来没有明确地在 认知任务，这种行走的大脑节奏可以服务于整合信息的根本目的 通过海马体来支持学习和记忆。这项研究的长期目标是 确定神经元如何协调行动以指导行为并开发新的治疗策略 使疾病中的大脑节律正常化。当前提案的主要目标是第一步 要实现我们的长期目标，就是要确定调节 电波传播，并预测大脑各区域的振荡活动。我们将通过测试 中心假说，通过隔膜和内嗅觉协调的theta振荡的传播 影响，可以被描述为弱非线性波，改变其动力学作为学习和 记忆具有以下特定目的：1)决定认知和隔膜输入对记忆的影响 海马theta波传播，2)确定内侧内嗅觉输入对海马区的影响 Theta波的传播，以及3)开发一种非线性算法来预测Theta波的传播。这个 基本原理是，这种方法将揭示波传播的基本原理，从而使新的 对正常大脑神经元协调和神经精神病学功能障碍机制的洞察 生病了。这一建议是创新的，因为我们将整合跨学科的理论和实证 发展对大规模神经元动力学的综合理解的方法。这件事的意义 其贡献是对学习和学习过程中海马区活动传播的前所未有的理解 记忆将提供对信息的时间协调的洞察力，开发关键的 为了解精神疾病中认知如何受到干扰奠定了基础。

Title: Testing and forecasting hippocampal theta wave propagation in learning and memory Abstract: Psychiatric disease states are associated with profound deficits in cognition that can severely compromise one's ability to live independently. In order to understand and effectively treat mental health disorders, it is necessary to determine how the information that supports adaptive behaviors is relayed across large networks of neurons. Brain rhythms, such as local field potential oscillations, have been hypothesized to organize neural circuit processing on multiple timescales in order to coordinate thought and action. Moreover, abnormalities in brain rhythms have been observed in humans afflicted with schizophrenia, autism, bipolar disorder, and a wide array of other neurological diseases. Among the neural oscillations affected by psychiatric diseases is the hippocampal theta rhythm, which is critical for learning and memory and is disrupted in schizophrenia and anxiety disorders. Importantly, the theta oscillation has been found to propagate along the hippocampal dorsoventral axis. Although the propagating theta wave has never been explicitly examined in the context of a cognitive task, this traveling brain rhythm could serve the fundamental purpose of integrating information across the hippocampus in support of learning and memory. The long-term goal of this research is to determine how neurons act in concert to guide behavior and to develop novel therapeutic strategies for normalizing brain rhythms in disease. The primary objective of the current proposal, which is the first step toward attaining our long-term goal, is to determine the behavioral and cellular mechanisms that modulate wave propagation, and to forecast oscillatory activity across brain regions. We will attain this by testing the central hypothesis that the propagation of the theta oscillation, coordinated via septal and entorhinal influences, can be described as a weakly nonlinear wave, altering its dynamics as a function of learning and memory with the following specific aims: 1) Determine the influence of cognition and septal input on hippocampal theta wave propagation, 2) Determine the influence of medial entorhinal input on hippocampal theta wave propagation, and 3) Develop a nonlinear algorithm to forecast theta wave propagation. The rationale is that this approach will uncover fundamental principles of wave propagation that will enable new insight into neuronal coordination in the normal brain and mechanisms of dysfunction in neuropsychiatric illness. This proposal is innovative because we will integrate cross-disciplinary theoretical and empirical approaches to develop an integrated understanding of large-scale neuronal dynamics. The significance of this contribution is an unprecedented understanding of activity propagation in the hippocampus during learning and memory that will provide insights into the temporal coordination of information, developing the critical foundation for understanding how cognition is disrupted in psychiatric disease.