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Glutamatergic compounds for treating drug addiction: Preclinical models

Glutamatergic compounds for treating drug addiction: Preclinical models
用于治疗药物成瘾的谷氨酸化合物：临床前模型
批准号：
9555587
负责人：
Eliot Gardner
金额：
$34.91万
依托单位：
NATIONAL INSTITUTE ON DRUG ABUSE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9555587
关键词：
Addictive BehaviorAnimal ModelBehaviorBiochemicalBiological AssayBrainBudgetsChemicalsCollaborationsCuesDrug AddictionDrug IndustryElectrical Stimulation of the BrainExposure toGlutamatesGoalsHigh Pressure Liquid ChromatographyIntravenousLaboratory AnimalsLiteratureMediatingMetabotropic Glutamate ReceptorsMicrodialysisNeurotransmittersPeer ReviewPharmaceutical PreparationsPolymerase Chain ReactionPre-Clinical ModelProteinsPsychological reinforcementPublicationsRNARelapseReportingResearchResearch Project GrantsReverse TranscriptionRewardsRoleSamplingSelf AdministrationStressSystemTechniquesWestern BlottingWorkaddictioncravingfollow-upin vivointerestpre-clinicalpreference

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中文摘要
翻译
由于预算和人员编制的极大削减，本报告所述期间，这一研究项目没有取得任何进展。这是不幸的，因为该项目在前几年一直是我们最有成效的研究努力之一，导致在同行评议的科学文献中发表了大量文章。我们目前正在寻求外部研究合作，特别是与制药行业内的实体合作，这可能使我们能够再次开展这项工作，并跟进我们在前几年就这一项目获得的有希望的发现。
英文摘要
Due to extremely severe cuts in budget and staffing, no progress was made on this research project during the reporting period. This is unfortunate, as this project had been - in previous years - one of our most productive research endeavors, resulting in a large number of publications in the peer-reviewed scientific literature. We are presently pursuing external research collaborations, especially with entities within the pharmaceutical industry, that may allow us to once again pursue this work and follow up on the promising findings that we had obtained in previous years on this project.
期刊论文(7)
专著(0)
科研奖励(0)
会议论文
N-acetylaspartylglutamate (NAAG) inhibits intravenous cocaine self-administration and cocaine-enhanced brain-stimulation reward in rats.
DOI： 10.1016/j.neuropharm.2009.06.016
发表时间： 2010-01
期刊： Neuropharmacology
影响因子： 4.7
作者： [Xi ZX, Kiyatkin M, Li X, Peng XQ, Wiggins A, Spiller K, Li J, Gardner EL]
通讯作者： Gardner EL
Activation of mGluR7s inhibits cocaine-induced reinstatement of drug-seeking behavior by a nucleus accumbens glutamate-mGluR2/3 mechanism in rats.
DOI： 10.1111/j.1471-4159.2010.06851.x
发表时间： 2010-09-01
期刊： Journal of neurochemistry
影响因子： 4.7
作者： [Li X, Li J, Gardner EL, Xi ZX]
通讯作者： Xi ZX
Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism.
DOI： 10.1038/npp.2008.236
发表时间： 2009-06
期刊： Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子： --
作者： []
通讯作者：
Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism.
DOI： 10.1111/j.1471-4159.2009.06478.x
发表时间： 2010-01
期刊： Journal of neurochemistry
影响因子： 4.7
作者： [Xi ZX, Li X, Peng XQ, Li J, Chun L, Gardner EL, Thomas AG, Slusher BS, Ashby CR Jr]
通讯作者： Ashby CR Jr
Endocannabinoid brain mechanisms and addiction
Dopamine D3 receptor antagonists for treating drug addiction: Preclinical models
Basic brain mechanisms underlying drug addiction, craving, and relapse
Basic brain mechanisms underlying drug addiction, craving, and relapse
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