Translational Cancer Imaging

摘要-转化癌症成像（TCI）共享资源 翻译癌症成像（TCI）资源的目标是为癌症中心成员提供 全面的成像服务，将促进基础，临床，以及转化癌症研究， - 是的TCI从最初的小动物成像核心扩展到包括四个关键单元：1） 回旋加速器和成像探头; 2）临床前成像; 3）临床研究成像;和4）图像分析。的 扩大成像核心不仅将提高我们的整体成像能力，而且还将大大加快 癌症研究从基础科学向临床应用发展，先进的工具和渠道建立 在TCI中。新的回旋加速器和成像探头单元包含支持所需的所有设备 放射性药物开发、临床翻译和用于分子成像研究的探针生产。 主要组成部分包括最先进的放射化学研究设施，具有高能量（16.5 MeV）GE PETtrace回旋加速器，多个自动化放射化学处理模块，洁净室，热室和其他 辅助设备动物成像单元有一个新的小鼠3,000笼持有单位和房屋11 动物研究专用成像设备件，包括9.4T动物MR扫描仪，1只动物 PET/CT扫描仪，一台SPECT/CT扫描仪，一台用于标本的高分辨率微型CT，一台微型CT系统 对于体内研究，两个高分辨率超声系统，三个IVIS光学成像系统和一个3D 层析荧光成像系统。由于所有设备都位于一个集中的空间， 临床前成像单元能够提供非侵入性成像，纵向研究，以及 在各种癌症应用中对动物模型进行多模态成像。人体成像装置配备了 配备一台3 T全身MRI扫描仪、一台一体化MRI/PET扫描仪、一台PET/CT扫描仪和一台整体 全身7 T核磁共振扫描仪，全部专用于临床研究。同样，它们都位于一个集中的空间 就在动物影像室的上方这些专用仪器有力地支持了转化癌 以无缝的方式进行研究。图像分析股将继续提供先进的分析工具， 定制软件和数据存储和传输工具，以支持成像研究。下一次融资 TCI提出了两个主要目标，即1）加强成像探测服务的基础设施， 转化发展; 2）加强癌症研究中的动物和人类成像支持。我们将 加强基础设施，为临床前和临床应用提供成像探头开发和生产服务。 临床使用。同时，我们将继续扩大我们的成像能力，改善基础设施， 平移成像研究，促进人体成像研究。

ABSTRACT -Translational Cancer Imaging (TCI) Shared Resource The goal of the Translational Cancer Imaging (TCI) resource is to provide cancer center members with a comprehensive imaging service that will facilitate basic, clinical, as well as translational cancer research at UNC. The TCI has expanded from the original Small Animal Imaging Core to include four key units: 1) Cyclotron & Imaging Probe; 2) Preclinical Imaging; 3) Clinical Research Imaging; and 4) Image Analysis. The expansion of the imaging core will not only enhance our overall imaging capability, but also greatly expedite cancer research developed from basic science to clinical application with advanced tools and channels built within the TCI. The new Cyclotron and Imaging Probe unit contains all the equipment needed to support radiopharmaceutical development, clinical translation, and probe production for molecular imaging studies. Key components include state of the art radiochemistry research facility with a high energy (16.5 MeV) GE PETtrace cyclotron, multiple automated radiochemical processing modules, clean room, hot cells and other ancillary equipment. The Animal Imaging unit has a new mouse 3,000 cage holding unit and houses eleven pieces of imaging equipment dedicated for animal studies, including a 9.4T animal MR scanner, one animal PET/CT scanner, one SPECT/CT scanner, one high resolution microCT for specimens, one microCT systems for in vivo studies, two high resolution ultrasound system, three IVIS optical imaging systems, and one 3D tomographic fluorescence imaging system. With all the equipment located in one centralized space, the preclinical imaging unit is capable of providing non-invasive imaging, longitudinal studies, as well as multimodality imaging on animal models in various cancer applications. The Human Imaging unit is equipped with one 3T whole body MRI scanner, one integrated MRI/PET scanner, one PET/CT scanner, and one whole body 7T MRI scanner, all dedicated for clinical research. Again, they are all located in one centralized space right above the animal Imaging unit. These dedicated instruments strongly support the translational cancer research in a seamless fashion. The Image Analysis unit will continue to provide advanced analysis tools, customized software, and data storage and transfer tools to support imaging studies. For the next funding cycle, the TCI proposes two major aims, namely 1) to enhance infrastructure for imaging probe services and translational development; 2) strengthen animal and human imaging support in cancer research. We will enhance the infrastructure to provide imaging probe development and production services for both preclinical and clinical usage. Meanwhile, we will continue expanding our imaging capability, improving infrastructures for translational imaging study, and promoting human imaging research.