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Small Animal PET/CT for Preclinical Imaging Research

用于临床前成像研究的小动物 PET/CT

基本信息

批准号：
9274662
负责人：
Zibo Li
金额：
$ 83.45万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-03-17 至 2020-03-16
项目状态：
已结题

项目摘要

Abstract: A molecular imaging initiative has been underway at the University of North Carolina at Chapel Hill (UNC-Chapel Hill) for the recent several years. Specifically, with the recent expansion of the UNC Biomedical Research Imaging Center (BRIC) radiochemistry program, there is an ever increasing need for PET focused research in both preclinical and clinical areas at UNC. Indeed, our small animal PET/CT scanners have been a valuable research tool for basic and translational research by investigators from a broad range of clinical and basic science departments and schools, and in a wide variety of investigation areas. Unfortunately, our current small animal PET/CT scanner is outdated and lacks the desired imaging capabilities needed for many research projects. Specifically, the deficiencies include but not limited to the inability for whole body dynamic scan, the limited resolution and sensitivity, and slow CT acquisition process, etc. More seriously, this system has been extremely unreliable with 423 hours downtime in the past 12 month. We urgently need to enhance PET imaging capability by replacing the current scanner. This proposal requests fund for the acquisition of a small animal PET/CT system for use at UNC BRIC, as a shared research tool for users in UNC BRIC, Lineberger Cancer Center, School of Pharmacy, and School of Medicine. Moreover, investigators from nearby universities (such as NC State University) will also benefit from this technology. Indeed, with dedicated clinical PET/CT scanner available for research at UNC BRIC, it is essential to obtain the corresponding small animal imaging counterparts with cutting edge technology, which will seamlessly integrates preclinical PET/CT research with clinical research studies. The requested nanoScan PET/CT will be used by investigators in the fields of medicine, cardiology, neurology, biochemistry, molecular biology, and pharmaceutical sciences. Addition of the nanoScan PET/CT will significantly increase the productivity of UNC investigators who are working in various areas of basic and translational research (including cancer, neuro, and diabetic research), enabling access to in vivo systems to evaluate fundamental biological processes. The discoveries and advancements made by our investigators will ultimately have a direct positive impact on public health.

摘要：查佩尔山的北卡罗来纳州大学（UNC-Chapel）正在进行一项分子成像计划希尔）近几年来。具体来说，随着最近生物医学研究中心的扩大，成像中心（金砖四国）放射化学计划，有越来越多的需要PET重点研究，临床前和临床领域。事实上，我们的小动物PET/CT扫描仪已经成为一种有价值的研究工具，供来自广泛临床和基础科学领域的研究人员进行基础和转化研究部门和学校，并在各种各样的调查领域。不幸的是，我们现在的小动物 PET/CT扫描仪已经过时，缺乏许多研究项目所需的成像能力。具体而言，不足包括但不限于无法进行全身动态扫描，分辨率和灵敏度，以及CT采集过程缓慢等。更严重的是，该系统已被非常不可靠，在过去的12个月里有423个小时的停机时间。我们迫切需要增强PET成像通过更换现有的扫描仪。该提案要求提供资金，用于购买一个小动物PET/CT系统，供金砖四国使用，为北卡罗来纳大学BRIC、Lineberger癌症中心、药学院和医学院的用户提供共享研究工具药此外，附近大学（如北卡罗来纳州立大学）的研究人员也将受益于这个技术。事实上，随着专用的临床PET/CT扫描仪可用于研究在金砖四国，它是获得具有尖端技术的相应小动物成像对应物至关重要，将临床前PET/CT研究与临床研究无缝集成。请求的nanoScan PET/CT将由医学、心脏病学、神经病学、生物化学、分子生物学、生物医学生物学和制药科学。增加nanoScan PET/CT将显著增加在基础研究和转化研究的各个领域工作的研究人员的生产力（包括癌症，神经和糖尿病研究），使访问体内系统，以评估基础生物学流程.我们的研究人员所取得的发现和进展最终将对我们的研究产生直接的积极影响。对公众健康的影响。