The Persistence of Longevity Across Generations: An Exploratory Investigation of Grandchildren of ex-POWs

其他项目信息-项目摘要/摘要 长寿的代代相传--对长寿老人孙辈的探索性调查 前战俘 这个项目的主要目的是调查是否有任何证据表明 孙子孙女的祖传父性创伤。越来越多的人担心健康会通过 世世代代的贫穷，导致家庭健康状况和社会经济地位持续不佳。母性 在怀孕期间暴露在饥荒、感染和心理压力下与健康不良有关。 儿童出生和成年，但研究父性健康在人类中的代际传递 种群数量很少。该项目的调查结果将为传播 并确定是否需要在更大范围内进行进一步研究 是否应该收集更多的信息来阐明任何潜在的 传播，是否应该继承后代，如果应该，应该继承哪些后代 紧随其后。 这个项目将研究父亲的前战俘身份传递给联邦陆军退伍军人的子女 美国内战(1861-185年)。它将建立在以前NIA资助的数据库的子样本上，该数据库收集了 联邦陆军1,999名前战俘和8,500名非战俘退伍军人的53,000多名儿童的记录 指标、代际进程和老龄化“，国家投资局赠款P01AG10120，PI：COSTA)。数据限制 排除了在最近的人群中进行类似的研究。 该项目将调查祖先父亲的前战俘创伤是否会传递给 退伍军人影响他们的寿命，以及这种传播是否具有性别特异性。身份将来自于 前战俘在营地条件最差时的孙子孙女与前战俘在营地时的孙子孙女的比较 条件更好，而且不是战俘。分析将需要获得死亡信息，以便 联邦军队退伍军人的孙女和孙子，前战俘的孙子孙女样本过多。 分析样本将包括23,000多名孙女和孙子的记录 他们活到45岁，战后出生于2847名退伍军人。 研究祖先暴露的影响将增加我们对人类健康和福祉的理解 并可为卫生干预措施提供信息。

OTHER PROJECT INFORMATION – Project Summary/Abstract The Persistence of Longevity Across Generations: An Exploratory Investigation of Grandchildren of ex-POWs The overarching purpose of this project is to investigate whether there is any evidence for the transmission of ancestral paternal trauma to grandchildren. There is growing concern that health can be transmitted across generations, leading to the persistence of poor health and socioeconomic status within families. Maternal exposure to famines, infection, and psychological stress during pregnancy has been linked to poor health of children at birth and in adulthood, but studies of the intergenerational transmission of paternal health in human populations are few. The findings from this project will provide “proof of concept” for the transmission of paternal trauma in a human population and determine whether further studies are needed in a larger population, whether additional information should be collected to elucidate the mechanisms of any potential transmission, whether future generations should be followed, and, if so, which descendants should be followed. This project will study the transmission of paternal ex-POW status to children of Union Army veterans of the US Civil War (1861-5). It will build on a subsample of a previously NIA funded database that has collected the records of more than 53,000 children of 1,999 Union Army ex-POW and 8,500 non-POW veterans (“Early Indicators, Intergenerational Processes, and Aging,” NIA grant P01AG10120, PI: Costa). Data limitations preclude similar studies in more recent populations. The project will investigate whether ancestral paternal ex-POW trauma is transmitted to the grandchildren of veterans to affect their longevity and whether this transmission is sex-specific. Identification will come from a comparison of grandchildren of ex-POWs when camp conditions were at their worst, ex-POWs when camp conditions were better, and non-POWs. The analysis will require obtaining death information for the granddaughters and grandsons of Union Army veterans, with an over-sample of grandchildren of ex-POWs. The analytical sample will consist of the records of more than 23,000 granddaughters and grandsons who survived to age 45 and who were born after the war to 2,847 veterans. Studying the effects of ancestral exposures will increase our understanding of the health and well-being of descendants and can inform health interventions.