Expansion of normative database for wide-band acoustic immittance measures to include children and abnormal ears and analyses of data across studies and underlying assumptions

项目总结/摘要 本工作旨在开发宽带声导抗（阿威）测量作为一种非侵入性的听觉 诊断工具，其中阿威是指测量值的集合，包括吸光度、功率 电抗、阻抗和相关量。这些措施的潜在用途包括：（1）检测 鼓室导抗测试不太成功的新生儿和幼儿耳中的中耳炎，（2） 传导性听力损失的原因（例如，听小骨脱位、听小骨固定），以及（3）监测 由颅内压变化引起的中耳硬度变化。拟议的工作前- 倾向于世界上唯一的在线阿威数据库和相应的网站，这是在 该补助金的第一个周期，从阿威测量标准成人耳朵，也包括耳朵， 婴儿和儿童的特殊病理和耳朵。建议的工作还包括（1）实验室- 基于声学测量和CT耳道扫描，以了解为什么两个FDA批准的阿威 测量系统在其测量中具有系统差异，以及（2）利用数据库 进行跨研究的数据分析，以比较正常耳朵和耳朵的阿威测量结果， 特定的病理，以确定阿威功能，最好区分正常的耳朵和 耳朵有特定的病理。第二个重点是研究性教育 史密斯学院是一所女子文理学院，本科工程师 neering学生将积极参与拟议工作的所有领域，目标是鼓励 让他们在研究生阶段继续接受教育。

PROJECT SUMMARY / ABSTRACT This work aims to develop wideband acoustic immittance (WAI) measures as a noninvasive auditory diagnostic tool, where WAI refers to the collection of measurements that include absorbance, power reflectance, impedance, and related quantities. Potential use of these measures includes (1) detection of fluid in newborn and young infant ears where tympanometry is less successful, (2) identification of the cause of a conductive hearing loss (e.g., fluid, disarticulated ossicle, fixed ossicle), and (3) monitoring changes in middle-ear stiffness that result from intracranial pressure changes. The proposed work ex- tends the world's only online WAI database and corresponding website, which was developed during the first cycle of this grant, from WAI measurements on normative adult ears to also include ears with specific pathologies and ears of babies and children. The proposed work also includes (1) laboratory- based acoustical measurements and CT ear-canal scans to understand why the two FDA-approved WAI measurement systems have systematic differences in their measurements and (2) utilizing the database to perform data analyses across studies to compare WAI measures on both normal ears and ears with specific pathologies in order to identify WAI features that best differentiate between normal ears and ears with specific pathologies. A second emphasis of the proposed work is the research-based education of undergraduate students at Smith College, an all-women's liberal arts college. Undergraduate engi- neering students will be actively involved in all areas of the proposed work, with the goal of encouraging them to continuing their education at the graduate level.