High Intensity Interval Training for Knee Osteoarthritis

项目总结/摘要 拟议项目的总体目标是改善膝关节骨关节炎患者的预后 (OA)使用一种新的锻炼方法，可以包括在疾病的康复方法， 高强度间歇训练（HIIT）。与膝关节OA的其他体力活动干预不同 目前可用的或正在研究中的HIIT需要最少的时间（每次10分钟的锻炼，2 具有快速提供身体功能、疼痛和其他健康改善的潜力 方面拟议研究的基本原理是建立在HIIT在几种临床治疗中有效的证据基础上的。 人群;然而，在OA患者中的可行性是未知的，他们面临着独特的和大量的 运动的挑战，特别是功能限制和疼痛。这条研究路线的主要假设 膝关节OA患者将坚持HIIT，报告该计划的良好耐受性，并将在临床上 在基于性能的身体功能，以及膝盖力量，身体成分， 和心肺功能，完成HIIT后。一项12岁以下儿童的单臂可行性和概念验证研究， 将在30例症状性膝关节OA患者中进行为期一周的HIIT干预。本研究具有创新性 因为它探索了一种新的康复方法，具有广泛的普遍性， 改善膝关节OA患者身体功能和疼痛。在目标1中，多学科小组， OA专业知识，身体活动， 心脏病学， 和生物统计学，将审查一个 12-在有症状的膝关节OA患者中进行为期一周的HIIT计划。我们将确定依从性和耐受性 通过6周和12周评估，HIIT、可接受性以及患者招募和保留率。在 目标2，我们将确定6周和12周时基于表现的体格检查结果的短期变化， 功能、膝关节OA症状负担（疼痛）、平衡、等长膝关节伸肌和屈肌力量（因素 与身体功能和症状性膝关节OA进展相关）、心肺功能和身体 参与HIIT干预的症状性膝关节OA患者的组成。如果HIIT 干预被证明是耐受性良好和有希望的，这项初步研究的结果将奠定基础， 一项大型随机对照试验，以确定HIIT作为一种革命性方法的疗效， 加强膝关节OA的康复和管理。

Project Summary/Abstract The overall goal of the proposed project is to improve outcomes among individuals with knee osteoarthritis (OA) using a novel exercise method that can be included in rehabilitation approaches for disease management: high intensity interval training (HIIT). Unlike other physical activity interventions for knee OA currently available or under investigation, HIIT requires minimal time (10 minutes of exercise per session, 2 times per week) with the potential to quickly provide improvements in physical function, pain, and other health aspects. The rationale for the proposed research is built upon the proof that HIIT is effective in several clinical populations; however, the feasibility is unknown among individuals with OA, who face unique and substantial challenges to exercise, particularly functional limitations and pain. The main hypotheses of this line of research is that patients with knee OA will adhere to HIIT, report good tolerability of the program, and will have clinically important improvements in performance-based physical function, as well as knee strength, body composition, and cardiorespiratory fitness, after completing HIIT. A single-arm feasibility and proof-of-concept study of a 12- week HIIT intervention will be conducted in 30 patients with symptomatic knee OA. This study is innovative because it explores a novel rehabilitation approach, with potential for widespread generalizability, to improve physical function and pain in people with knee OA. In Aim 1, the multidisciplinary team, with expertise in OA, physical activity, cardiology, and biostatistics, will examine the feasibility and acceptability of a 12-week HIIT program in patients with symptomatic knee OA. We will determine adherence to and tolerability of HIIT, acceptability, and recruitment and retention rates of patients through 6- and 12-week assessments. In Aim 2, we will determine short-term changes at 6- and 12-weeks in outcomes of performance-based physical function, knee OA symptomatic burden (pain), balance, isometric knee extensor and flexor strength (factors associated with physical function and symptomatic knee OA progression), cardiorespiratory fitness, and body composition among patients with symptomatic knee OA participating in a HIIT intervention. If the HIIT intervention is shown to be well-tolerated and promising, results of this preliminary study will lay the foundation for a large randomized controlled trial to establish the efficacy of HIIT as a revolutionary approach for enhancing the rehabilitation and management of knee OA.