A Novel Mobile Health Fitness Program for AYA Childhood Cancer Survivors

描述(由申请人提供)：幸运的是，治疗的进步导致了美国儿童癌症幸存者数量的增长。不幸的是，这些幸存者面临着治疗的负面晚期效应的风险，包括心血管疾病和过早死亡。 缺乏运动会加剧这些风险。尤其是儿童癌症的青少年幸存者报告说，在接受治疗后，持续的体力活动显著减少。Katie Devine Recuay博士寻求获得这一职业发展奖，以成为儿科癌症幸存者的独立调查者，专门关注青少年和年轻成人(Aya)幸存者的关切。她的长期目标是促进健康的行为，提高儿童癌症幸存者的生活质量。短期目标包括以下方面的专门培训：(1)使用移动健康“mHealth”技术实施行为干预，(2)Aya癌症生存的生物学和临床方面，(3)使用行为干预进行多地点随机临床试验(RCT)，以及(4)运动生理学和评估方法。与她的导师和顾问团队一起，她制定了一项培训计划，其中包括实现这些目标的具体活动，包括正式课程、研讨会、心血管和身体健康评估的动手培训，以及一个由癌症控制、行为科学和运动科学专家组成的多学科团队指导的研究项目。拟议的研究项目包括创建针对癌症的移动应用程序(APP)，以补充基于群体的每周健身计划，并对这一技术增强计划的有效性进行试点测试。这款应用程序将根据阿亚幸存者的意见和她在这一领域所做的初步工作来开发。在试点RCT中，88名Aya幸存者将随机接受技术增强的健身计划或等待名单控制。主要结果是客观地衡量心血管健康状况。次要结果包括肌肉力量、与健康相关的生活质量和疲劳。我们假设，与等待名单对照组相比，干预组的参与者将在主要和次要结果上表现出更大的改善。该项目在mHealth技术的使用和对儿童癌症幸存者的干预的特异性方面具有创新性。拟议的职业发展计划将促进迪瓦恩博士转变为一名独立调查员，在Aya生存问题和在行为干预中使用mHealth技术方面拥有专业知识。

DESCRIPTION (provided by applicant): Advances in treatment have fortunately led to a growth in the number of childhood cancer survivors in the US. Unfortunately, these survivors are at-risk for negative late effects from treatment, including cardiovascular disease and early death. Physical inactivity can exacerbate these risks. Adolescent survivors of childhood cancers in particular have reported significant declines in physical activity that persist following treatment Katie Devine Recuay, PhD, seeks this career development award to become an independent investigator in pediatric cancer survivorship, specializing in the concerns of adolescent and young adult (AYA) survivors. Her long-term goals are to promote healthy behaviors and enhance quality of life for AYA survivors of childhood cancers. Short-term goals include specialized training in: (1) the use of mobile health "mHealth" technology for implementing behavioral interventions, (2) biological and clinical aspects of AYA cancer survivorship, (3) the conduct of multi-site randomized clinical trials (RCTs) using behavioral interventions, and (4) exercise physiology and methods of assessment. Along with her mentors and advisory team, she has developed a training plan with specific activities to reach these goals through a combination of formal coursework, seminars, hands-on training in the assessment of cardiovascular and physical fitness, and a research project mentored by a multidisciplinary team of experts in cancer control, behavioral sciences, and exercise science. The proposed research project involves the creation of a cancer-specific mobile application (app) that complements a group-based weekly fitness program, and pilot testing of the effectiveness of this technology- enhanced program. The app will be developed based on input from AYA survivors and preliminary work she has done in this area. In the pilot RCT, 88 AYA survivors will be randomized to either the technology-enhanced fitness program or waitlist control. The primary outcome is objectively measured cardiovascular fitness. Secondary outcomes include muscle strength, health-related quality of life, and fatigue. We hypothesize that participants in the intervention group will demonstrate greater improvement across primary and secondary outcomes compared with the waitlist control. This project is innovative in its use of mHealth technology and the specificity of the intervention to AYA survivors of childhood cancers. The proposed career development plan will facilitate Dr. Devine's transition to an independent investigator with expertise in AYA survivorship concerns and the use of mHealth technology in behavioral interventions.