A Novel Mobile Health Fitness Program for AYA Childhood Cancer Survivors

描述（由申请人提供）：幸运的是，治疗的进步导致了美国儿童癌症幸存者数量的增长。不幸的是，这些幸存者面临治疗的负面晚期效应的风险，包括心血管疾病和早期死亡。 缺乏身体活动会加剧这些风险。特别是儿童癌症的青少年幸存者报告了治疗后持续的身体活动显着下降Katie Devine Recuay博士寻求这个职业发展奖，成为儿科癌症生存的独立调查员，专门关注青少年和年轻成年人（AYA）幸存者。她的长期目标是促进健康行为，提高儿童癌症AYA幸存者的生活质量。短期目标包括以下方面的专业培训：（1）使用移动的健康“mHealth”技术实施行为干预，（2）AYA癌症生存的生物学和临床方面，（3）使用行为干预进行多地点随机临床试验（RCT），以及（4）运动生理学和评估方法。沿着她的导师和咨询团队，她已经制定了一个培训计划，通过正式的课程，研讨会，在心血管和身体健康的评估实践培训相结合的具体活动，以达到这些目标，并由癌症控制，行为科学和运动科学的多学科专家团队指导的研究项目。拟议的研究项目涉及创建一个癌症专用的移动的应用程序（app），以补充基于团体的每周健身计划，并对该技术增强计划的有效性进行试点测试。该应用程序将根据AYA幸存者的意见和她在这方面所做的初步工作开发。在试点随机对照试验中，88名AYA幸存者将被随机分配到技术增强健身计划或候补名单对照组。主要结果是客观测量的心血管健康。次要结果包括肌肉力量，健康相关的生活质量和疲劳。我们假设干预组的参与者与等待名单对照组相比，在主要和次要结局方面表现出更大的改善。该项目在使用移动健康技术和针对儿童癌症AYA幸存者的干预措施方面具有创新性。拟议的职业发展计划将促进Devine博士过渡到一名独立的调查员，他在AYA生存问题和在行为干预中使用mHealth技术方面具有专业知识。

DESCRIPTION (provided by applicant): Advances in treatment have fortunately led to a growth in the number of childhood cancer survivors in the US. Unfortunately, these survivors are at-risk for negative late effects from treatment, including cardiovascular disease and early death. Physical inactivity can exacerbate these risks. Adolescent survivors of childhood cancers in particular have reported significant declines in physical activity that persist following treatment Katie Devine Recuay, PhD, seeks this career development award to become an independent investigator in pediatric cancer survivorship, specializing in the concerns of adolescent and young adult (AYA) survivors. Her long-term goals are to promote healthy behaviors and enhance quality of life for AYA survivors of childhood cancers. Short-term goals include specialized training in: (1) the use of mobile health "mHealth" technology for implementing behavioral interventions, (2) biological and clinical aspects of AYA cancer survivorship, (3) the conduct of multi-site randomized clinical trials (RCTs) using behavioral interventions, and (4) exercise physiology and methods of assessment. Along with her mentors and advisory team, she has developed a training plan with specific activities to reach these goals through a combination of formal coursework, seminars, hands-on training in the assessment of cardiovascular and physical fitness, and a research project mentored by a multidisciplinary team of experts in cancer control, behavioral sciences, and exercise science. The proposed research project involves the creation of a cancer-specific mobile application (app) that complements a group-based weekly fitness program, and pilot testing of the effectiveness of this technology- enhanced program. The app will be developed based on input from AYA survivors and preliminary work she has done in this area. In the pilot RCT, 88 AYA survivors will be randomized to either the technology-enhanced fitness program or waitlist control. The primary outcome is objectively measured cardiovascular fitness. Secondary outcomes include muscle strength, health-related quality of life, and fatigue. We hypothesize that participants in the intervention group will demonstrate greater improvement across primary and secondary outcomes compared with the waitlist control. This project is innovative in its use of mHealth technology and the specificity of the intervention to AYA survivors of childhood cancers. The proposed career development plan will facilitate Dr. Devine's transition to an independent investigator with expertise in AYA survivorship concerns and the use of mHealth technology in behavioral interventions.