Core C - Fieldwork Core

核心C实地工作-摘要： 胃腺癌是全球癌症死亡的第三大原因，也是感染的首要原因。 与癌症相关的死亡率，与显著的地理变异性有关。在拉丁美洲，地理变异性是 表现为“海拔之谜”，尽管幽门螺杆菌感染率同样很高，但与之形成鲜明对比的是 在农村山区和沿海地区的发病率分别较低。 太平洋沿岸地区。核心C建立在长期、多产和具有成本效益的研究基础上 哥伦比亚和中美洲的基础设施，每个都在高风险山区和 风险较低的沿海地区，并包容了种族和民族多样性的人口。田野调查 核心C代表实现本计划项目目标的中心。核心C将监督所有人的护理 在拉丁美洲开展的研究活动，并提供流行病学数据和人类 在所有项目和岩芯中使用的样品。我们的核心C具体目标是：(1)在哥伦比亚，执行所有 与哥伦比亚化学预防队列中的受试者监督和后续行动有关的活动， 关注沿着组织病理级联进展的个人，从慢性胃炎到萎缩或 肠上皮化生、异型增生/腺癌。项目1、2和3的核心研究将集中在 这群进步者。(2)在中美洲，履行与招聘新员工有关的职能 中美洲幽门螺杆菌和人类遗传祖先横断面研究的对象。这3个网站 包括高风险山区(洪都拉斯科潘)和位于 加勒比(洪都拉斯特拉)和太平洋(尼加拉瓜莱昂)。这将提供一个无与伦比的研究平台 对于拟议的遗传祖先研究，进一步检查和探索我们令人兴奋的 关于不和谐的共同进化和胃癌风险的研究结果。(3)监管研究基础设施 在哥伦比亚和中美洲，包括数据管理、标本采集和生物储存库。 核心C将管理计划项目流行病学数据库，以协调与 项目和其他核心，提供全面的质量控制，并跟踪生物群落。核心C将确保所有 数据和标本在国内、哥伦比亚和中美洲被取消身份。总而言之，哥伦比亚 在本计划项目的整个过程中，现场工作核心都已到位，我们现在将采用此P01 在一个令人兴奋的新方向上，通过在中美洲增加现有网站来提供无与伦比的平台 为我们提出的关于胃癌发生机制的临床翻译研究。

Core C FIELDWORK – Summary: Gastric adenocarcinoma is the third leading cause of global cancer mortality and the leading cause of infection- associated cancer mortality, with marked geographic variability. In Latin America, geographic variability is manifest by the “altitude enigma” where despite similarly high H. pylori infection rates, sharply contrasting high and low incidence rates are observed in the mountainous versus coastal regions, respectively, in the countries of the Pacific littoral zone. Core C is built upon long-standing, productive, and cost-effective research infrastructures in Colombia and Central America, each with sites in the high risk mountainous regions and lower risk coastal areas, and inclusive of populations that are racially and ethnically diverse. The Fieldwork Core C represents the epicenter to achieve the goals of this Program Project. Core C will oversee care of all the research activities carried out in Latin America, and provide the epidemiological data and human specimens to be used in all Projects and Cores. Our Core C specific aims are: (1) In Colombia, to execute all activities related to the oversight and follow-up of subjects in the Colombia chemoprevention cohort, with a focus on individuals who progress along the histopathology cascade, from chronic gastritis, to atrophy or intestinal metaplasia, and to dysplasia/adenocarcinoma. Studies central to Projects 1, 2, and 3 will focus on this group of progressors. (2) In Central America, to perform functions related to the recruitment of new subjects for the Central America cross-sectional H. pylori and human genetic ancestry study. The 3 sites include the high risk mountainous area (Copán, Honduras), and the low risk coastal sites located on the Caribbean (Tela, Honduras) and Pacific (León, Nicaragua). This will provide an unparalleled research platform for the proposed genetic ancestry study, to further examine and explore the generalizability of our exciting findings regarding discordant co-evolution and gastric cancer risk. (3) To oversee the research infrastructures in Colombia and Central America, including data management, specimen collection and the biorepository. Core C will manage the Program Project epidemiology database to coordinate the interactions with the Projects and other Cores, provide overall quality control, and to track biospecimens. Core C will ensure that all data and specimens are de-identified in-country, in Colombia and Central America. In summary, the Colombia Fieldwork Core has been in place throughout the course of this Program Project, and we will now take this P01 in an exciting new direction by adding established sites in Central America to provide an unparalleled platform for our proposed clinical translational investigations into the mechanisms that govern gastric carcinogenesis.