Comparative Pathology Core

项目摘要 比较病理学核心是宾夕法尼亚大学学院的一个既定核心。 已整合到艾布拉姆森癌症中心(ACC)的兽医，并作为 新建立的共享资源，用于NCI审批和CCSG资金。因此，核心将使 ACC以满足使用动物模型的成员日益增长的需求。艾米·达勒姆，硕士，VMD，文凭 美国兽医病理学家协会(DACVP)副教授 兽医学院的病理生物学，开发和指导核心。达勒姆博士是一个董事会- 注册解剖兽医病理学家，在癌症动物模型方面具有丰富的经验，并 在整个过程中参与了许多与ACC成员和其他人的合作研究项目 宾夕法尼亚大学校区。动物大体和组织病理损伤的识别和准确解释 模型对于癌症研究的成功至关重要。目前，核心病理学家与ACC成员合作 来自多个研究项目，包括肿瘤生物学、癌症治疗、乳腺癌、 免疫生物学、放射生物学和成像，以及儿科肿瘤学。在已经推出的服务中 提供的是：小鼠表型，全面的玻片评估和解释，咨询，尸检 培训和光学显微镜检查。其他服务利用核心的组织学实验室提供 组织病理学切片制备，以及特殊组织化学和免疫组织化学染色。劳作 与设施主任达勒姆博士一起工作的是伊丽莎白·布扎博士，她是核心的技术总监和负责人 病理学家。Buza博士在小鼠病理学方面有专长，并在小鼠疾病模型方面进行了额外的培训 她来自诺华和杰克逊实验室，并与达勒姆博士共事多年。有几个 董事会认证的解剖病理学家，支持Durham博士和Buza博士，并可提供 专业知识取决于调查员的特殊需要。其中包括朱莉·英格尔斯博士 伊丽莎白·毛尔丁博士(皮肤病理学)和梅丽莎·S博士(口腔病理学和口腔病理学)。 免疫组织化学)。核心目前为12个行政协调委员会成员提供服务，这意味着行政协调委员会的成员翻了一番 自2013年7月宣布核心作为行政协调会共享资源以来的成员使用情况。因此，作为 使用老鼠模型的癌症研究继续扩大，ACC成员的核心利用率预计将 大幅增长。

Project Summary The Comparative Pathology Core is an established Core within the University of Pennsylvania School of Veterinary Medicine that has been integrated into the Abramson Cancer Center (ACC) and is presented as a newly established Shared Resource for NCI approval and CCSG funding. As such, the Core will enable the ACC to fulfill the growing needs of members who are using animal models. Amy Durham, MS, VMD, Diplomate of the American College of Veterinary Pathologists (DACVP) and Assistant Professor in the Department of Pathobiology at the School of Veterinary Medicine, developed and directs the Core. Dr. Durham is a board- certified anatomic veterinary pathologist with considerable experience in animal models of cancer, and has been involved in numerous collaborative research projects with members of the ACC and others throughout the Penn campus. Recognition and accurate interpretation of gross and histopathological lesions in animal models is essential for the success of cancer research. Currently, Core pathologists work with ACC members from multiple Research Programs, including Tumor Biology, Cancer Therapeutics, Breast Cancer, Immunobiology, Radiobiology and Imaging, and Pediatric Oncology. Among the services that have been provided are: mouse phenotyping, comprehensive slide evaluation and interpretation, consultation, autopsy training, and photomicroscopy. Additional services utilize the Core's histology laboratory to provide histopathology slide preparation, as well as special histochemical and immunohistochemical staining. Working with the Facility Director, Dr. Durham, is Dr. Elizabeth Buza, who is the Core's Technical Director and lead pathologist. Dr. Buza has expertise in mouse pathology and additional training in mouse models of disease from Novartis and Jackson Labs, and she has worked with Dr. Durham for several years. There are several board-certified anatomic pathologists who support Drs. Durham and Buza, and are available to provide specialty expertise depending on the investigator's particular needs. They include Dr. Julie Engiles (osteopathology), Dr. Elizabeth Mauldin (dermatopathology), and Dr. Melissa Sánchez (oral pathology and immunohistochemistry). The Core currently serves 12 ACC members which, represents a doubling in ACC member usage since the announcement of the Core as an ACC Shared Resource in July 2013. Thus, as cancer research using mouse models continues to expand, Core utilization by ACC members is predicted to grow substantially.