Cancer Biology Research Program

癌症生物学-项目摘要 癌症生物学研究计划(CB)的科学目标是了解分子机制 它定义了正常和肿瘤细胞的生长，以便识别和表征分子、途径和 参与肿瘤发展、生长和进展的过程可以作为有用的 生物标志物和/或作为癌症治疗和预防的新细胞靶点。Cb代表基本的 堪萨斯大学癌症中心(KUCC)的科学倡议，并由成员利用 以分子、生化和细胞为基础的方法来了解正常和癌细胞的行为。这个 CB的具体目标是：1)促进合作，加强对潜在机制的发现 肿瘤的发展、进展和恶性行为；以及2)利用基础科学发现 启发新的癌症治疗方法的临床前和临床发展。 CB有49名正式成员和12名准成员，来自KUMC、KU-Lawrence和 斯托尔斯。2015年，CB获得了近1700万美元的癌症相关同行评议资金(来自NCI的200万美元，1220万美元 其他NIH)。自2012年以来，CB成员发表了617篇文章，其中144篇(23%)是方案内的， 128人(21%)进行了计划间协作，315人(51%)进行了机构间协作。这些出版物 被引用超过5600次，平均期刊影响因子(JIF)为7.3,167(27%)有 Jif≥8. CB由Kristi Neufeld(KU-Lawrence)和Lineng Li(Stowers)共同领导，他们带来了互补 在细胞生物学、干细胞生物学、生物化学和翻译研究方面的科学专长，领导 经验和多样化的机构代表。丹尼·韦尔奇，基础科学和 Education和KUCC研究人员调查员Jim Calvet组成领导团队并代表 KUMC。通过研究务虚会、研讨会、研究促进方案内和方案间的协作 研讨会和有针对性的试点资金。CB在研究三种肿瘤方面利用了历史上的优势 KUCC集水区人口中发病率或死亡率过高的地点(GI，肾脏 和造血学)。但与疾病主题组织不同，CB成员拥有的专业知识 可分为四个学科主题：1)癌细胞生物学和干细胞生物学；2)细胞 增殖、分化和死亡；3)染色质组织和转录调控；4) 信号通路与发展。

Cancer Biology – Project Summary The scientific goal of the Cancer Biology research program (CB) is to understand the molecular mechanisms that define normal and neoplastic cell growth in order to identify and characterize molecules, pathways and processes that are involved in tumor development, growth and progression that can serve as useful biomarkers and/or as new cellular targets for cancer therapeutics and prevention. CB represents the basic science initiatives of The University of Kansas Cancer Center (KUCC) and is unified by member utilization of molecular, biochemical and cell-based approaches to understand normal and cancer cell behavior. The Specific Aims of CB are: 1) to promote collaboration that enhances discovery of the mechanisms underlying tumor development, progression and malignant behavior; and 2) to leverage basic science discoveries to inspire pre-clinical and clinical development of novel cancer therapies. CB has 49 full members and 12 associate members from 17 departments located at KUMC, KU-Lawrence and Stowers. In 2015, CB garnered nearly $17M in cancer-related, peer-reviewed funding ($2M from NCI, $12.2M other NIH). CB members have published 617 articles since 2012 of which 144 (23%) had intra-programmatic, 128 (21%) had inter-programmatic and 315 (51%) had inter-institutional collaborations. These publications have been cited over 5,600 times, have an average journal impact factor (JIF) of 7.3 and 167 (27%) have a JIF≥8. CB is jointly led by Kristi Neufeld (KU-Lawrence) and Linheng Li (Stowers), who bring complementary scientific expertise in cell biology, stem cell biology, biochemistry and translational research, leadership experience and diverse institutional representation. Danny Welch, Associate Director for Basic Science & Education and Jim Calvet, KUCC Research Staff Investigator, round out the leadership team and represent KUMC. Intra- and inter-programmatic collaborations are fostered by research retreats, seminars, research symposia and targeted pilot funding. CB has taken advantage of historical strengths in the study of three tumor sites over-represented in either incidence or mortality rate in the KUCC catchment area population (GI, kidney and hematopoietic). But rather than a disease-based thematic organization, CB members have expertise that can be organized into four discipline-based themes: 1) Cancer Cell Biology and Stem Cell Biology; 2) Cell Proliferation, Differentiation and Death; 3) Chromatin Organization and Transcriptional Regulation; and 4) Signaling Pathways and Development.