Admin Core

该计划的长期目标是开发一个发现自然的平台， 产品抗菌剂，并为药物开发提供线索。该平台将解决 抗菌剂发现的当前瓶颈-缺乏良好的先导化合物。三个PI来自 不同的机构参与了这个雄心勃勃的项目。相关的项目有：（一）没有文化 用于发现新型抗菌剂的细菌; II）通过转录组的抗生素去复制 分析; III）抗菌剂评价和开发。我们的核心创新 建议的项目是使用快速去复制的转录谱，以确定有吸引力的 未培养的细菌所携带的化合物。行政核心的目标是 促进和促进项目目标的实现。 项目主任将负责整个项目，并监督 行政核心。项目主任（PD/PI）的主要优先事项是促进 三个研究项目的进展和成功，从而使该计划取得成功 项目他的努力将得到一个计划咨询委员会和 行政核心经理。行政核心经理将协调日常 三个相互关联的项目的PI和人员之间的互动。经理会 与PD/PI、组成项目PI和执行委员会以及项目 咨询委员会协助进行科学、行政和财政监督。 经理将在整个项目中促进沟通，并安排小组 为项目成员和项目会议举行的会议和电话会议 咨询委员会。经理将处理该计划的行政细节， 与NIAID的互动，并协助编写定期报告给NIAID。的 经理将定期向PD/PI提供关于每个项目财务状况的报告， 组织项目负责人年度会议，审查并调整项目 预算.核心经理将与IT专家一起创建和维护一个计划 网站该网站将使项目参与者能够收集、储存和分析他们的数据， 该网站还将用于传播关于该中心所有项目的信息， 程序.

The long-term goal of the Program Project is to develop a platform for the discovery of natural product antimicrobials, and to provide leads for drug development. This platform will resolve the current bottleneck in antimicrobial discovery – lack of good lead compounds. Three PIs from different Institutions are involved in this ambitious project. The related projects are I) Uncultured bacteria for the discovery of novel antimicrobials; II) Antibiotic dereplication by transcriptome analysis; III) Antimicrobial evaluation and development. The essential innovation of our proposed project is to use rapid dereplication by transcription profiling to identify attractive compounds harbored by uncultured bacteria. The objective of the Administrative core is To promote and facilitate the achievement of the goals of the Program Project. The Program Director will be responsible for the overall program and for overseeing the Administrative core. The major priority of the Program Director (PD/PI) is to promote the progress and success of the three research projects and thereby the success of the Program Project. His efforts will be augmented by a Program Advisory Committee and by the Administrative Core Manager. The Administrative Core Manager will coordinate the day-to-day interactions among the PIs and personnel of the three interrelated projects. The Manager will work with the PD/PI, component project PIs and Executive Committee and the Program Advisory Committee to assist with the scientific, administrative and fiscal oversight. The Manager will facilitate communications throughout the Program, and arrange group meetings and teleconferences for members of the project and for meetings of the Program Advisory Committee. The Manager will handle the administrative details of the Program and, interactions with the NIAID and assist in the preparation of regular reports to the NIAID. The Manager will provide the PD/PI with regular reports on the financial status of each project and organize annual meetings of the Project Leaders to review and make adjustments to project budgets. The Core Manager will work with an IT expert to create and maintain a Program website. The website will enable project participants to collect, store and analyze their data from all of the projects of the center; the website will also serve to disseminate information on the Program.