Social-ecological factors influencing receptivity to Zika virus and the efficacy of interventions in communities along the Texas-Mexico border

项目总结 全球出现登革热病毒、基孔圭纳病毒和寨卡病毒 证明蚊媒病毒能够在世界各地传播，并导致显著的 公共卫生负担。这些病毒在城市传播周期中保持不变， 病毒的持续存在取决于环境的生态接受度，而生态接受度在很大程度上取决于 蚊子与人类接触的频率。此外，以社区为基础的干预措施 参与蚊子综合管理的公民活动是由文化决定的 以及社会经济因素。这些调节蚊媒病毒风险的社会生态因素 和管理的有效性在美国大陆还没有得到充分的认识或解决 各州。我们的中心假设是不同的群落在生态接受性上有很大的不同 由于社会因素而导致的传播和应对疫情的能力。这一假说将 通过以下具体目标进行测试：1)量化室内和室外蚊子物种的存在 和丰度，并确定与室内蚊子种群相关的风险因素，2)评估 以CDC自杀性妊娠诱卵器为基础的媒介控制蚊虫数量的效果 跨群落和不同媒介物种之间(埃及伊蚊、白纹伊蚊、库蚊 Ququiefasciatus)，3)确定预测社区参与公民科学运动的因素 以及默许实施媒介控制策略。这项研究将在#年的8个社区进行。 南得克萨斯州(伊达尔戈县和卡梅伦县)采用配对小区实验设计。我们会 使用糖饵站的新应用来监测成年蚊子的数量，该诱饵站可以确定 主要蚊媒种类和相对丰度。这一新的抽样 策略将与Sentinel ago陷阱进行比较，Sentinel ago陷阱是一种成熟的成人监控工具 蚊子很多。预期结果包括1)更好地评估出现风险 对于像ZIKV和CHIKV这样在美国社区中在人-蚊子循环中被放大的病毒， 2)对美国社区室内暴露风险的关键评估，以及3)确定必要性 使疾病管理策略适应当地特有的特定社会生态因素 社区。这项研究解决了对多样化缓解战略的需求，这些战略应该是 在不同社会经济水平的不同社区的景观镶嵌中使用， 对限制病媒传播的疾病提出了明显的挑战。最终，这项研究是 预计将对制定综合缓解战略产生积极的转化影响 有效地动员当地社区对新出现的病毒威胁做出快速反应。

PROJECT SUMMARY The global emergence of Dengue virus (DENV), Chikunguyna virus (CHIKV) and Zika virus (ZIKV) demonstrate the ability of mosquito-borne viruses to spread around the world and result in significant public health burden. These viruses are maintained in urban transmission cycles and the ability of the virus to persist depends on the ecological receptivity of the environment that depends largely on the frequency of mosquito-human contact. Additionally, the ability of a community-based intervention with engaged citizens activity participating in integrated mosquito management is determined by cultural and socioeconomic factors. These social-ecological factors that modulate mosquito-borne viral risk and efficacy of management have not been fully appreciated or addressed in the continental United States. Our central hypothesis is that different communities vary starkly in their ecological receptivity to transmission and capacity to respond to outbreaks as a result of social factors. This hypothesis will be tested by the following Specific Aims: 1) quantify indoor and outdoor mosquito species presence and abundance and identify risk factors associated with indoor mosquito populations, 2) evaluate the efficacy of the CDC Autocidal Gravid Ovitrap (AGO)-based vector control on mosquito abundance across communities and between different vector species (Aedes aegypti, Aedes albopictus, Culex quinquefasciatus), 3) identify factors that predict community participation in citizen science campaigns and acquiescence to implement vector control strategies. This study will occur in eight communities in South Texas (Hidalgo and Cameron Counties) using a paired plot experimental design. We will monitor adult mosquito abundance using a novel application of a sugar bait station that determines the species and relative abundance of the primary mosquito vector species. This new sampling strategy will be compared to the Sentinel AGO trap, which is an established tool to monitor adult mosquito abundance. The expected outcomes include 1) a better assessment of the emergence risk for viruses like ZIKV and CHIKV that are amplified in a human-mosquito cycles in U.S. communities, 2) a critical assessment of indoor exposure risk in U.S. communities, and 3) determining the necessity to adapt disease management strategies to specific social-ecological factors endemic to local communities. This research addresses the need for diverse mitigation strategies that should be employed across landscape mosaics of different communities of variable socioeconomic levels that present distinct challenges to limit vector-borne disease transmission. Ultimately, the research is expected to have a positive translational impact on the development of integrated mitigation strategies that effectively engage local communities for rapid response to emerging viral threats.