TJU Modernization of Bluemle Life Science Building Sanitation Facility

 描述(由申请人提供)：本申请旨在为托马斯·杰斐逊大学Bluemle生命科学大楼(BLSB)动物设施的新隧道垫圈和双门高压灭菌器提供资金。托马斯·杰斐逊大学(TJU)是美国历史最悠久的学术健康中心之一，于1824年成立了杰斐逊医学院(2014年更名为杰斐逊西德尼·基梅尔医学院)。杰斐逊大学的许多校友和教职员工对医学界的重大事件做出了重大贡献，或曾参与其中。其中包括在内战期间开发了第一个军用野战救护车系统；发现了黄热病的原因；开发了心肺机；进行了世界上第一个心脏直视手术，开发了第一个预防医学健康风险评估系统，并开发了第一个人造肌腱。TJU致力于在研究中对动物进行人道关怀和使用，并因此运营着USDA、OLAW和AAALAC认证的设施。研究组合中的很大一部分包括动物模型的使用。目前，有125名首席研究人员在校园内根据376项IACUC批准的协议进行研究。动物资源公司目前在BLSB全天候运营一家工厂，占地约16,700平方米。英国《金融时报》住房和动物护理支助空间集中在11楼。Bluemle生命科学大楼(BLSB)建于1991年，是用于湿台实验室研究的大多数啮齿动物的所在地。根据目前的人口普查，BLSB设施约占整个TJU动物计划的62%。目前的许多动物模型现在都是转基因和/或免疫受损的啮齿动物。除了这些模型，研究人员现在还利用人类和小鼠的病原体来确定免疫途径和潜在的疫苗靶点。这种类型的研究对动物护理人员和研究人员都提出了挑战。必须对使用的笼子进行适当的消毒，以保护动物免受不必要的混杂感染。同样重要的是，在进入公共笼舍卫生区之前，必须销毁任何实际或潜在的危险物质。超过预期寿命的设备在运行中断和能源利用方面造成多方面的低效。本申请要求更换已使用20多年的现有隧道垫圈和双门高压灭菌器。采购和安装该设备将提高人员效率、减少停机时间、显著节省运营成本并减少对环境的负面影响。

 DESCRIPTION (provided by applicant): This application seeks funding for a new tunnel washer and double door autoclave for the Bluemle Life Science Building (BLSB) animal facility at Thomas Jefferson University. Thomas Jefferson University (TJU) is one of the oldest academic health centers in the United States, with establishment of its Jefferson Medical College in 1824 (renamed the Sidney Kimmel Medical College at Jefferson in 2014). A number of alumni and faculty of Jefferson have made significant contributions to or have been involved in notable events in medicine. Among these are the development, during the Civil War, of the first military field ambulance system; discovery of the cause of yellow fever; development of the heart lung machine; performance of the world's first open heart surgery, development of the first preventative medicine health risk appraisal system and development of the first artificial tendon. TJU is dedicated to the humane care and use of animals in research and as such, operates USDA-, OLAW- and AAALAC-accredited facilities. A significant portion of the research portfolio includes the use of animal models. Currently there are 125 principal investigators conducting research under 376 IACUC-approved protocols on campus. Animal Resources currently operates a 24/7/365 facility in BLSB in approximately 16,700 sq. ft. of housing and animal care support space in a centralized configuration on the eleventh floor. The Bluemle Life Science Building (BLSB), built in 1991, houses the majority of rodents used in wet bench laboratory research. BLSB facilities represent about 62% of the entire TJU animal program by current census. Many of the current animal models are now transgenic and/or immunocompromised rodents. In addition to these models, investigators are now employing the use of pathogens, both human and murine, to identify immune pathways and potential vaccine target sites. This type of research poses challenges to both the animal care personnel and the researcher. It is imperative that the caging used is appropriately sanitized to protect the animals from unwanted confounding infections. Likewise it is critical that any real or potential hazardous agents are destroyed prior to entering common cage sanitation areas. Equipment which has exceeded its expected longevity results in multiple inefficiencies both in operational disruption and energy utilization. This application is requesting the replacement of existing tunnel washer and double-door autoclave that have been in use for more than 20 years. The procurement and installation of this equipment will result in increased personnel efficiency, less down time, significant operational savings and decreased negative environmental impact.