Bioinformatics

摘要 将高通量原始数据转换为具有生物意义的信息的分析过程可以 对临床、翻译和基础研究人员提出了重要的挑战。作为中心的一部分 芝加哥大学医学综合癌症中心(UCCCC)研究信息学(CRI) 生物信息学核心设施(BiCF)提供旨在实现生物科学的服务和专业知识 该司(BSD)的调查人员充分利用了当前的高通量技术。核心作品 与UCCCC生物统计核心基金(BCF)和基因组学核心基金(GCF)密切协调 作用域和数据流。核心的主要目标是：1)通过以下方式提供专家分析服务 开发和应用生物信息学策略分析复杂基因组学、蛋白质组学和 遗传学数据；2)为教师提供生物信息学方面的咨询、培训和教育 3)提供赠款申请支持，包括全面发展生物信息学 赠款的组成部分、成本分析、支持函以及记录工具和专业知识的可用性 完成这项研究表明。 BiCF结合了强大的计算资源、先进的分析工具和致力于 将大量原始数据转化为有意义的结果的安全性。核心使用CRI的高- 性能计算群集和大规模存储资源，可以进行复杂的分析 在并行或分布式环境中执行以产生快速的数据处理速度，从而提高应用程序 性能和成本效益。目前，BiCF一直是UCCCC开发的核心设施 授权期；基于UCCCC成员的积极使用和生物信息学在癌症中的重要作用 研究表明，在这一竞争性的续订应用中，BiCF被提议作为完整的CCSG核心。

ABSTRACT The analysis process that transforms high-throughput raw data into biologically meaningful information can present important challenges to clinical, translational, and basic researchers alike. As part of the Center for Research Informatics (CRI), the University of Chicago Medicine Comprehensive Cancer Center (UCCCC) Bioinformatics Core Facility (BiCF) offers services and expertise designed to enable Biological Sciences Division (BSD) investigators to take full advantage of current high-throughput technologies. The Core works closely with the UCCCC Biostatistics Core Facility (BCF) and the Genomics Core Facility (GCF) to coordinate scope and data flows. The major objectives of the Core are: 1) To provide expert analysis services by developing and applying bioinformatics strategies for the analysis of complex genomics, proteomics and genetics data; 2) To provide consultation, training and education to faculty regarding bioinformatics approaches; and 3) To provide grant application support, including fully developing the bioinformatics components of a grant, cost analysis, letters of support, and documenting the availability of tools and expertise to complete the research indicated. The BiCF combines the use of powerful computing resources, advanced analytics tools, and a commitment to security to transform large amounts of raw data into meaningful results. The Core uses the CRI’s high- performance computing cluster and large-scale storage resources, with which complex analytics can be executed in parallel or distributed environments to produce fast data processing rates, improving application performance and cost effectiveness. The BiCF has been a UCCCC Developing Core Facility during the current grant period; based on its robust usage by UCCCC members and the essential role of bioinformatics in cancer research, the BiCF is proposed as a full CCSG Core in this competing renewal application.