2021 Natural Products & Bioactive Compounds Gordon Research Conference & Gordon Research Seminar

项目摘要 天然产物一直是药物发现和药物开发的灵感来源。他们的 独特和多样的分子支架已经刺激了对生物合成途径、分子生物学和分子生物学的研究。 目标，并启发了新的合成策略，这使得他们的结构确认和准备。 总的来说，这些努力推动了该领域的发展，并使寻找下一代药物成为可能。 未解决的人类疾病，如多重耐药细菌感染，癌症和其他罕见的遗传病， 疾病因此，毫不奇怪，大约三分之二的所有上市药物具有天然药物活性。 产品起源2021年会议的总体目标是继续发扬传统， 在科学前沿的演讲和讨论，以进一步推动广泛和不断 天然产品的发展。一个独特而多样化的科学家小组将被召集起来， 科学学科，并源于不同的经验水平，背景和人口统计。还有， 与会者之间的协作和跨学科的互动将得到鼓励和培养，同时也 培养新兴科学家。大约30个演讲式的演讲将 突出未发表研究并引发激烈讨论。补充性非正式研究 讨论，通常75，将发生在一个轻松的，社会设置通过互动海报会议。此外该 会议形式为专业发展和社会互动提供了重要机会 与会者之间。因此，此R13应用程序的目标是为Gordon请求部分资金 研究会议（08/01/21 - 08/06/21）和相关的戈登研究研讨会（07/31/21 - 08/01/21） 在新罕布什尔州安多弗的普罗克特学院举办关于天然产品和生物活性化合物的研讨会， 学生，博士后，早期职业科学家，妇女和其他代表性不足的少数民族， 高质量的科学会议。会议将由经常出席会议的Amber J. Onorato博士主持 他是北方肯塔基州大学化学和生物化学系的副教授。的 副主席将是菲利普·R。Kym，执行董事兼药物化学领导团队负责人， AbbVie，由前任主席提名并在2019年GRC会议上由与会者选出（19年7月28日- 2019年2月8日）。

Project Summary Natural products have consistently served as an inspiration for drug discovery and drug development. Their unique and diverse molecular scaffolds have stimulated investigation of biosynthetic pathways, molecular targets, and inspired new synthetic strategies, which allowed for their structural confirmation and preparation. Collectively, these efforts have advanced the field and enabled the search for the next generation of drugs for unmet human diseases such as multidrug resistant bacterial infections, cancers, and other rare genetic diseases. Therefore, not surprisingly, approximately two-thirds of all marketed pharmaceuticals have natural product origins. The overall objective of the 2021 meeting is to continue the tradition of featuring exceptional presentations and discussions at the forefront of science in order to further advance the broad and constantly evolving field of natural products. A unique and diverse group of scientists will be assembled that span scientific disciplines, and stem from various experience levels, backgrounds, and demographics. Also, collaborative and cross-disciplinary interactions among attendees will be encouraged and fostered, while also incorporating the development of emerging scientists. Approximately, 30 lecture-style presentations will highlight unpublished research and stimulate rigorious discussion. Complementary informal research discussions, typically 75, will occur via interactive poster sessions in a relaxed, social setting. In addition, the conference format provides significant opportunity for professional development and social interactions between attendees. Therefore, the goal of this R13 application is to request partial funding for the Gordon Research Conference (08/01/21 – 08/06/21) and associated Gordon Research Seminar (07/31/21 – 08/01/21) on Natural Products and Bioactive Compounds at Proctor Academy in Andover, NH in order to recruit graduate students, postdocs, early career scientists, women, and other underrepresented minorities to an excellent and high quality scientific conference. The meeting will be chaired by Dr. Amber J. Onorato, a frequent attendee and associate professor in the department of chemistry and biochemistry at Northern Kentucky University. The vice-Chair will be Philip R. Kym, Executive Director and Head of the Medicinal Chemistry Leadership Team at AbbVie, who was nominated by previous chairs and elected by conferees at the 2019 GRC (07/28/19 – 08/02/19).