ROS-induced SPIO Targeted Platform for Transarterial Liver Cancer Therapy

标题：经动脉途径治疗肝癌的SPIO-Gox结合物 摘要： 肝细胞癌是世界上第六大常见恶性肿瘤，位居 在与癌症相关的死亡中排名第三，每年新诊断的病例超过70万例。 迫切需要改进这种疾病的治疗方法。癌细胞以三种方式死亡： 细胞凋亡、坏死和自噬。细胞内活性氧的显著增加 物种(ROS)可引起不可逆转的氧化损伤，通过两者导致细胞死亡 细胞凋亡和坏死。最近，我们的团队创造了一个新颖的SPIO-Gox纳米平台， ROS和代谢衰竭疗法的协同作用。利用体外和体内研究，我们发现 这种纳米平台可以产生非常高水平的ROS和高效的肿瘤细胞 毁灭。通过靶向传递和最大限度地提高该制剂的治疗效果 最小的全身毒性将是有效的临床翻译的关键。经动脉 化疗栓塞术(TACE)，化疗直接进入肿瘤供给区 动脉，是目前治疗不能切除的肝细胞癌的标准。TACE协同交付 在显著降低毒性的同时进行肿瘤血管栓塞的化疗 由于定向投放。在这个项目中，我们计划利用我们创新的SPIO-Gox 采用经动脉给药技术的动脉消融纳米平台研究其潜力 在肝癌治疗中的应用。如果成功，我们可能会推进肝癌的科学研究 使用这种新型的声纳疗法进行治疗。

Title: SPIO-GOx conjugate for transarterial liver cancer therapy Abstract: Hepatocellular carcinoma (HCC) is the sixth most common malignancy worldwide and ranks third amongst cancer-related deaths, with over 700,000 new cases diagnosed each year. Improved therapies for this disease is urgently needed. Cancer cells die in three ways: apoptosis, necrosis and autophagy. A significant increase in intracellular reactive oxygen species (ROS) can cause irreversible oxidative damage, leading to cell death through both apoptosis and necrosis. Recently, our team created a novel SPIO-GOx nanoplatform, synergizing ROS and metabolic depletion therapies. Using in vitro and in vivo studies, we found this nanoplatform could produce very high levels of ROS and highly efficient tumor cell destruction. Maximizing the therapeutic profile of this agent through targeted delivery and minimal systemic toxicity will be crucial for effective clinical translation. Transarterial chemoembolization (TACE), where chemotherapy is delivered directly into tumor-feeding arteries, is the current standard of care for unresectable HCC. TACE synergizes delivery of chemotherapy with embolization of tumor blood vessels while significantly minimizing toxicity due to targeted delivery. In this project, we plan to leverage our innovative SPIO-GOx theranostic nanoplatform with trans-arterial delivery technology to investigate the potential application in liver cancer treatment. If successful, we may advance the science of liver cancer treatment using this novel theranostic nanotherapy.