糖尿病合并症和 MERS 冠状病毒发病机制-猫眼课题宝

糖尿病合并症和 MERS 冠状病毒发病机制

批准号：

9294969

负责人：

Matthew Bryan Frieman

金额：

$19.54万

依托单位：

UNIVERSITY OF MARYLAND BALTIMORE

依托单位国家：

美国

项目类别：

财政年份：

2016

资助国家：

美国

项目状态：

已结题

起止时间：

2016-06-13 至 2018-05-31

来源：

https://reporter.nih.gov/project-details/9294969

关键词：

Affect Animal Model Brain Camels Case Fatality Rates Case Study Cessation of life Chinese People Chiroptera Clinical Clinical Data Communities Comorbidity Coronaviridae Coronavirus Coronavirus Infections Country Development Diabetes Mellitus Diabetic mouse Dipeptidyl-Peptidase IV Disease Disease Outbreaks Drug Targeting Endopeptidases FDA approved Future GCG gene Glare Glucose Government Health Personnel Heart Diseases Hospitals Human Immune response Immunosuppression Infection Inflammatory Response Insulin Jordan Kidney Failure Knowledge Lead Life Lung Middle East Middle East Respiratory Syndrome Coronavirus Mus Neurotransmitters Non-Insulin-Dependent Diabetes Mellitus Outcome Pathogenesis Pathogenicity Patients Persons Proteins Public Health Role Saudi Arabia South Korea Syndrome T-Lymphocyte Testing Virus Virus Replication Viverridae Work blood glucose regulation chemokine cohort comparative coronavirus receptor cytokine diabetic in vivo inhibitor/antagonist macrophage monocyte mouse model novel permissiveness receptor respiratory respiratory virus transmission process

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中文摘要

翻译

项目摘要在这里，我们试图确定糖尿病在中东呼吸综合征中的作用冠状病毒（MERS-CoV）发病机制。MERS-CoV于2012年在沙特阿拉伯出现导致超过1700例感染，病死率约为40%。大多数致命的 MERS-CoV感染与合并症有关，糖尿病是最常见的科摩罗。我们将使用MERS-CoV的小鼠模型来识别先前存在的2型糖尿病加重MERS-CoV疾病，糖尿病如何改变炎症反应以及预防MERS-CoV，如果针对糖尿病调节剂的药物可以保护小鼠免受MERS-CoV感染。

英文摘要

Project Summary Here we seek to identify the role of diabetes in Middle East Respiratory Syndrome Coronavirus (MERS-CoV) pathogenesis. MERS-CoV emerged in 2012 in Saudi Arabia leading to over 1700 infections with a ~40% case fatality rate. The majority of lethal MERS-CoV infections are associated with comorbidity, with diabetes as the top comorbidity. We will use a mouse model of MERS-CoV to identify if preexisting Type 2 diabetes exacerbates MERS-CoV disease, how diabetes alters the inflammatory response and protection from MERS-CoV and if drugs targeting a regulator of diabetes can protect mice from MERS-CoV.

期刊论文(2)

专著(0)

科研奖励(0)

会议论文

Human Monoclonal Antibody Cocktail for the Treatment or Prophylaxis of Middle East Respiratory Syndrome Coronavirus.

DOI： 10.1093/infdis/jiab036

发表时间： 2022-05-16

期刊：

The Journal of infectious diseases

影响因子： --

作者：

[Sivapalasingam S, Saviolakis GA, Kulcsar K, Nakamura A, Conrad T, Hassanein M, Sumner G, Elango C, Kamal MA, Eng S, Kyratsous CA, Musser BJ, Frieman M, Kantrowitz J, Weinreich DM, Yancopoulos G, Stahl N, Lipsich L]

通讯作者： Lipsich L