Cancer Biology Research Program

癌症生物学-项目摘要 癌症生物学研究计划（CB）的科学目标是了解癌症的分子机制。 定义正常和肿瘤细胞生长，以识别和表征分子、途径和 参与肿瘤发展、生长和进展的过程， 生物标志物和/或作为癌症治疗和预防的新的细胞靶标。CB代表基本的 堪萨斯大学癌症中心（KUCC）的科学倡议，并通过成员利用统一 分子，生物化学和细胞为基础的方法来了解正常和癌细胞的行为。的 CB的具体目标是：1）促进合作，促进发现潜在的机制 肿瘤的发展，进展和恶性行为; 2）利用基础科学发现， 激发了新型癌症疗法临床前和临床开发。 CB有49个正式成员和12个准成员，来自位于KUMC，KU-Lawrence和 斯托尔斯2015年，CB获得了近1700万美元的癌症相关同行评审资金（200万美元来自NCI，1220万美元来自 其他NIH）。自2012年以来，CB成员发表了617篇文章，其中144篇（23%）是项目内的， 128个（21%）有方案间合作，315个（51%）有机构间合作。这些出版物 已被引用超过5，600次，平均期刊影响因子（JIF）为7.3，167（27%） JIF≥8。 CB由Kristi Neufeld（KU-Lawrence）和Linheng Li（Stowers）共同领导，他们带来了互补的 细胞生物学、干细胞生物学、生物化学和转化研究方面的科学专长，领导力 经验和多样化的机构代表性。Danny Welch，基础科学和 教育和吉姆卡尔维，KUCC研究人员调查员，圆了领导团队，并代表 KUMC。研究静修、研讨会、研究促进了项目内和项目间的合作 专题讨论会和有针对性的试点供资。CB在三种肿瘤的研究中利用了历史优势 KUCC集水区人群中发病率或死亡率过高的地点（GI，肾脏 和造血）。但是，CB成员不是一个以疾病为基础的专题组织，而是拥有专门知识， 可分为四个学科为基础的主题：1）癌细胞生物学和干细胞生物学; 2）细胞 增殖、分化和死亡; 3）染色质组织和转录调节;以及4） 信号通路和发展。

Cancer Biology – Project Summary The scientific goal of the Cancer Biology research program (CB) is to understand the molecular mechanisms that define normal and neoplastic cell growth in order to identify and characterize molecules, pathways and processes that are involved in tumor development, growth and progression that can serve as useful biomarkers and/or as new cellular targets for cancer therapeutics and prevention. CB represents the basic science initiatives of The University of Kansas Cancer Center (KUCC) and is unified by member utilization of molecular, biochemical and cell-based approaches to understand normal and cancer cell behavior. The Specific Aims of CB are: 1) to promote collaboration that enhances discovery of the mechanisms underlying tumor development, progression and malignant behavior; and 2) to leverage basic science discoveries to inspire pre-clinical and clinical development of novel cancer therapies. CB has 49 full members and 12 associate members from 17 departments located at KUMC, KU-Lawrence and Stowers. In 2015, CB garnered nearly $17M in cancer-related, peer-reviewed funding ($2M from NCI, $12.2M other NIH). CB members have published 617 articles since 2012 of which 144 (23%) had intra-programmatic, 128 (21%) had inter-programmatic and 315 (51%) had inter-institutional collaborations. These publications have been cited over 5,600 times, have an average journal impact factor (JIF) of 7.3 and 167 (27%) have a JIF≥8. CB is jointly led by Kristi Neufeld (KU-Lawrence) and Linheng Li (Stowers), who bring complementary scientific expertise in cell biology, stem cell biology, biochemistry and translational research, leadership experience and diverse institutional representation. Danny Welch, Associate Director for Basic Science & Education and Jim Calvet, KUCC Research Staff Investigator, round out the leadership team and represent KUMC. Intra- and inter-programmatic collaborations are fostered by research retreats, seminars, research symposia and targeted pilot funding. CB has taken advantage of historical strengths in the study of three tumor sites over-represented in either incidence or mortality rate in the KUCC catchment area population (GI, kidney and hematopoietic). But rather than a disease-based thematic organization, CB members have expertise that can be organized into four discipline-based themes: 1) Cancer Cell Biology and Stem Cell Biology; 2) Cell Proliferation, Differentiation and Death; 3) Chromatin Organization and Transcriptional Regulation; and 4) Signaling Pathways and Development.