Identifying risk factors of Alzheimer's disease and related dementias in older Chinese immigrants

项目摘要 过去几十年来，中国移民人口一直在增加。尽管他们的数量越来越多， 对中国移民的健康状况知之甚少。随着移民人口的老龄化， 迫切需要了解他们的认知健康和患阿尔茨海默病及相关疾病的风险 疾病（AD/ADRD）是老年人常见的健康问题。AD/ADRD是一种认知功能丧失- 思考，记忆或推理的能力-到了一定程度，它干扰了一个人的日常生活， 活动在所有关于移民与认知的研究中， 中国移民。迄今为止，关于移民与认知之间联系的现有研究结果好坏参半。一些 研究报告称，移民的认知功能比美国出生的人差，而其他研究发现， 功能或无差异。在衡量方面，移民措施仅限于出生国、年龄 移民和停留时间。很少有人注意到移民前的影响（例如， 移民的原因和早期生活条件）和移民后的经历（例如，文化适应） 认知变化此外，认知功能在很大程度上是由整体认知定义的。知之甚少 关于移民对特定认知领域变化的影响，包括记忆领域， 执行功能和语言（称为AD/ADRD的早期认知标志物）。先前的研究 据报道，解释移民和认知之间关系的因素集群，包括：年龄， 性别、教育、抑郁、血管健康和遗传风险因素。纽约市是迄今为止 亚洲以外任何城市的中国人口。位于西奈山的阿尔茨海默病研究中心（ADRC）， 位于纽约市，在吸引和评估华裔美国老年人方面有着成功的记录， 现有的200多名中国老年移民的队列，根据 人口统计学变量、医学疾病、心理状况、功能状态和以下遗传风险 一个标准的痴呆症评估这项研究的目的是扩大痴呆症的评估，包括 移民前和移民后的经验。我们的目标是：（1）阐明 移民和认知，使用移民历史的综合措施，沿着认知重新， 评估;以及（2）通过利用 基线数据的完整性。将从ADRC招募100名性格鲜明的老年华人移民 在西奈山进行研究这项研究将为更大规模的研究提供初步数据， 移民与中国老年移民认知之间的关联。理解机制 通过移民经历影响移民人口的认知结果将指导 制定有针对性的干预措施，以预防AD/ADRD。

Project Summary Chinese immigrant population has been increasing for the last few decades. Despite their increasing numbers, very little is known about the health of Chinese immigrants. As the immigrant population becomes older, there is a pressing need to understand their cognitive health and risk of developing Alzheimer’s Disease and Related disorder (AD/ADRD), a common health problem in older individuals. AD/ADRD is a loss of cognitive function – ability to think, remember, or reason – to such an extent that it interferes with an individual’s day-to-day life and activities. Among all the study on immigration and cognition, only a few of them was focused specifically on Chinese immigrants. To date, existing findings on the linkages of immigration and cognition are mixed. Some studies reported worse cognitive function in immigrants than the US-born, whereas others found better cognitive function or no difference. In terms of measurement, immigration measures were limited to country born, age at immigration, and length of stay. Very little attention has been given to the influence of pre-immigration (e.g., reasons for immigration and early-life conditions) and post-immigration experiences (e.g., acculturation) on cognitive changes. In addition, cognitive function was largely defined by global cognition. Little is known regarding the effect of immigration on changes in specific cognitive domains, including areas of memory, executive function, and language (known as early cognitive markers of AD/ADRD). Previous studies have reported clusters of factors which explain the relationship between immigration and cognition, including: age, gender, education, depression, vascular health, and genetic risk factors. New York City has by far the highest Chines population of any city outside Asia. The Alzheimer’s Disease Research Center (ADRC) at Mount Sinai, located in New York City, has a successful record of engaging and evaluating Chinese American older adults, with an existing cohort of over 200 older Chinese immigrants who were fully characterized according to demographic variables, medical illnesses, psychological conditions, functional status, and genetic risks following a standard dementia evaluation. The purpose of this study is to expand the dementia evaluation to include measures of pre- and post-immigration experiences. We aim to: (1) elucidate the associations between immigration and cognition using comprehensive measures of immigration history along with a cognitive re- evaluation; and (2) identify potential mediators and moderators influencing such associations by leveraging the fullness of the baseline data. 100 well-characterized older Chinese immigrants will be recruited from the ADRC at Mount Sinai for the proposed study. This study will provide preliminary data for a larger study to examine the associations between immigration and cognition among older Chinese immigrants. Understanding mechanisms through which immigration experiences influence cognitive outcomes among the immigrant population will guide the development of tailored interventions to prevent AD/ADRD.