Africa Center for Biostatistical Excellence: Expanding biostatistical leadership for HIV/AIDS and TB Research

项目摘要 LMIC：南非 机构：开普敦斯泰伦博斯大学医学与健康科学学院 科学领域：艾滋病毒/艾滋病和结核病研究设计和方法的生物统计学 非洲生物统计卓越中心：扩大生物统计在艾滋病毒/艾滋病和 结核病研究 此应用程序是在响应FOA“福格蒂艾滋病毒研究培训计划，为低-和中等- 根据D43赠款机制（FOA PAR-19-283）， 支持斯泰伦博斯大学扩大生物统计学对艾滋病毒研究设计和方法的领导作用 南非的有 艾滋病毒/艾滋病和结核病仍然是撒哈拉以南非洲疾病负担的最大贡献者。的 新型SARS-CoV-2病毒感染导致的COVID-19疾病对脆弱的人构成威胁 卫生保健系统和基础设施。特别是，COVID-19对向人们提供护理的影响 艾滋病毒/艾滋病感染者可能会逆转几十年来在护理和治疗方案方面取得的成果。数据 驱动的解决方案和有针对性的研究和评估需要免费的领导团队，包括 生物统计学家本区域博士一级的生物统计学家严重短缺。 2017年，我们成功实施了艾滋病毒/艾滋病研究生物统计学硕士培训计划。 尽管缺乏受过高级培训的本地生物统计学家，我们动员了国际合作者， 协助教学和学生监督。为了我们培训计划的可持续性， 进展是培养当地未来的生物统计学领导者，他们将继续开展培训活动， 提供研究领导，以解决在SSA的健康问题的无数。 我们建议继续努力缩小撒哈拉以南非洲生物统计能力的差距，并开展研究 领导在斯泰伦博斯大学和整个地区。这次更新的具体目标是： 培训补助金是：（1）通过在斯泰伦博斯博士培训计划发展生物统计学的领导地位 大学;（2）通过硕士水平的学术课程继续建设生物统计能力，并扩大 我们使用电子学习平台的影响力;（3）巩固ACBE作为提供专业知识的领导者 发展生物统计学和数据管理，以支持艾滋病毒/艾滋病研究项目和计划 在撒哈拉以南非洲地区，领导艾滋病毒/艾滋病和结核病研究活动。

PROJECT SUMMARY LMIC: South Africa Institution: Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town Scientific Area: Biostatistics for HIV/AIDS and TB research design and methodology Africa Center for Biostatistical Excellence: expanding biostatistical leadership for HIV/AIDS and TB research This application is in response to the FOA “Fogarty HIV Research Training Program for Low- and Middle- Income Country Institutions” under the D43 grant mechanism (FOA PAR-19-283) and requests 5 years of support to expand biostatistics leadership for HIV research design and methodology at Stellenbosch University in South Africa. HIV/AIDS and TB remain the highest contributors to the burden of disease in sub-Saharan Africa (SSA). The COVID-19 disease resulting from infection with the novel SARS-CoV-2 virus poses a threat to the fragile healthcare system and infrastructure in SSA. In particular, COVID-19 effects on the delivery of care to people living with HIV/AIDS is likely to reverse gains in care and treatment programs achieved over decades. Data driven solutions and targeted research and evaluations demand complimentary teams of leaders, including biostatisticians. There is a huge deficit of doctoral level biostatisticians in the region. In 2017, we successfully implemented a masters’ level training program in biostatistics for HIV/AIDS research. Despite shortage in local biostatisticians with advanced training, we mobilized international collaborators to assist with teaching and student supervision. For sustainability of our training program, the natural progression is to train local future leaders in biostatistics who will continue the training initiatives and also provide research leadership to address the myriad of health problems in SSA. We propose to continue our efforts to bridge the gap in biostatistics capacity in SSA and develop research leadership at Stellenbosch University and the region at large. The specific objectives of this renewal of the training grant are to: (1) develop biostatistics leadership through a doctoral training program at Stellenbosch University; (2) continue building biostatistics capacity through a Masters’ level academic program and expand our reach using e-learning platforms; (3) consolidate the ACBE as a leader in providing professional development in biostatistics and data management to support HIV/AIDS research projects and programs within the SSA region and lead HIV/AIDS and TB research activities.