Deploying Intracortical Electrode Arrays to Record and Stimulate in a Tissue Volume

项目摘要 该项目的总体目标是开发一种新的皮质内电极阵列，其中插入一个扁平器械 然后在一定体积的组织内以受控的距离部署微电极。这种可部署的神经 接口将克服与皮层的记录和刺激相关联的两个关键限制：1）每个 插入仅导致电极放置在脑组织内的点处或沿着线性路径放置 不利的组织响应降低了记录性能。这项工作将导致可部署电极 使用形状变化的液晶聚合物（LCP）基板的阵列， 光刻法LCP基板在制造和处理期间保持平坦，然后在制造和处理之后展开。 植入到距植入部位最多200 µm的预定位置。中央 这项工作的前提是，从单次插入的电极部署可以实现体积 将微电极放置在小鼠皮层中，具有可行的记录和刺激能力， 四个月该团队公布的初步数据证明了创建可部署的 使用具有图案化微电极的形状变化液晶聚合物（LCP）基板的电极阵列 通过光刻。为了实现这一前提，提出了三个具体目标：1）制造和表征 可展开电极阵列，2）表征通过展开微电极引起的异物反应 阵列，以及3）通过慢性记录和测量表征部署微电极阵列 电极的电化学性能。该团队汇集了材料方面的必要专业知识 和微加工（PI Ware）和神经接口设计和表征（Co-I Pancrazio），以及 对植入器械的组织学反应（Co-I Capadona）。

Project Summary The overall goal of this project is to develop a new intracortical electrode array where a flat device is inserted that then deploys microelectrodes at controlled distances within a volume of tissue. This deployable neural interface will overcome two critical limitations associated with recording and stimulation of the cortex: 1) each insertion only leads to placement of electrodes at a point or along a linear path within brain tissue and 2) the recording performance is reduced by adverse tissue response. This work will result in deployable electrode arrays using shape-changing liquid crystal polymer (LCP) substrates with microelectrodes patterned by photolithography. The LCP substrates remain flat during fabrication and processing, then deploy after implantation to predetermined locations that are up to 200 µm away from the implantation site. The central premise of this work is that electrode deployment from a single insertion can enable volumetric placement of microelectrodes in mouse cortex with viable recording and stimulation capability for over four months. The team’s published and preliminary data demonstrate the feasibility of creating deployable electrode arrays using shape-changing liquid crystal polymer (LCP) substrates with microelectrodes patterned by photolithography. To realize this premise, three specific aims are proposed: 1) Fabricate and characterize deployable electrode arrays, 2) Characterize the foreign body response elicited by deploying microelectrode arrays, and 3) Characterize deploying microelectrode arrays by chronic recording and measuring electrochemical performance of the electrodes. The team brings together the necessary expertise in materials and microfabrication (PI Ware) and neural interface design and characterization (Co-I Pancrazio), and histological response to implanted devices (Co-I Capadona).