T32 University of Rochester Aging and Alzheimer's disease Training Program

虽然死于心脏病和癌症的老年人越来越少，但死于阿尔茨海默病和相关疾病的老年人越来越少。 痴呆症（ADRD）在过去二十年中上升了145%。寻求解决这一公共卫生问题的进展 危机是缓慢的。为了帮助加速ADRD的理解，治疗和预防方面的进展， 申请是为了建立一个NIA机构国家研究服务奖（T32），题为“大学 罗切斯特老龄化和阿尔茨海默病培训计划（UR-AADTP）"。长期以来， 在罗切斯特大学建立了对老龄化的基础和转化研究的优势， ADRD，我们的目标是加快发展和应用战略，以减少发病率， 与ADRD相关的死亡率。我们寻求支持六个博士前研究员（3年1插槽）在基础和 翻译研究计划谁将经历一个创新的课程，强调跨学科 科学，并通过与受痴呆症影响的人及其医疗保健的互动， 提供商UR-AADTP的主要目标是培养一批具有深度的早期科学家， 知识，技能，欣赏和经验的广度，以建立独立的职业生涯 痴呆症研究领域的研究人员;在跨学科的环境中工作， 积极地将研究转化为实践;并减少晚年认知障碍的死亡率。关于UR- AADTP T32具有以下具体目标： 目标1：我们将招募一批高素质的博士前培训生，他们致力于在 老龄化研究，保留他们，直到他们的培训完成，并支持他们成功过渡到后， 研究生学术职位。学员的多样性也将反映在他们的种族/民族背景中 因为它们所代表的科学学科和研究兴趣领域的范围。 目标2：通过课程，研讨会和讲习班，并指导研究经验，我们将提供UR- AADTP T32学员在基础和早期转化衰老的理论和方法方面具有坚实的基础 这是研究痴呆症发病机制和治疗发展所必需的研究。 目标3：通过促进受训人员与接受不同理论和实践培训的教员之间的互动， 方法论的老龄化和痴呆症研究，我们将刺激跨学科合作， 老龄化研究，加速痴呆症的研究，治疗和预防的进展。 目标4：通过有组织地接触临床环境，受痴呆症影响的人以及 关心他们，学员将欣赏研究和实践之间的联系，以加快 制定预防和减轻疾病的有效方法。 目标5：我们将严格评估该计划及其参与者（教师和学员）。

While fewer older adults are dying from heart disease and cancer, deaths from Alzheimer’s disease and related dementia’s (ADRD) have risen 145% in the last two decades. Progress to find a solution to this public health crisis has been slow. To help accelerate progress in the understanding, treatment, and prevention of ADRD, this application is for establishment of an NIA Institutional National Research Service Award (T32) titled, “University of Rochester Aging and Alzheimer’s Disease Training Program (UR-AADTP)”. Consistent with longstanding and established strengths at the University of Rochester in foundational and translational research on aging and ADRD, our goal is to accelerate the development and application of strategies to reduce the morbidity and mortality associated with ADRD. We seek support for six predoctoral fellows (3 slots in year 1) in basic and translational research programs who will undergo an innovative curriculum that emphasizes interdisciplinary science and informs their training through interactions with people affected by dementia and their health care providers. The UR-AADTP’s primary objective is to develop a cadre of early-stage scientists with the depth and breadth of knowledge, skills, appreciation, and experience necessary to establish careers as independent investigators in the area of dementia research; to work in an interdisciplinary environment designed to aggressively translate research to practice; and to reduce the toll of cognitive disorders in later life. The UR- AADTP T32 has these specific aims: Aim 1: We will recruit a diverse group of highly qualified predoctoral trainees who are committed to careers in aging research, retain them until their training is complete, and support their successful transitions to post- graduate academic positions. The trainees’ diversity will be reflected in their racial/ethnic backgrounds as well as the range of scientific disciplines and areas of research interest that they represent. Aim 2: Through courses, seminars and workshops, and mentored research experiences, we will provide UR- AADTP T32 trainees with a firm foundation in the theories and methods of basic and early translational aging research that are necessary for study of dementia pathogenesis and treatment development. Aim 3: By fostering interactions between trainees and faculty members trained in different theoretical and methodological approaches to aging and dementia research, we will stimulate interdisciplinary collaborations in aging research that accelerate the progress of dementia research, treatment and prevention. Aim 4: Through structured exposure to clinical settings, people affected by dementia, and the providers that care for them, trainees will appreciate the connections between research and practice necessary to accelerate the development of effective approaches to illness prevention and mitigation. Aim 5: We will rigorously evaluate the program and its participants (faculty and trainees).