Research Program: Breast & Ovary Cancers

项目摘要：乳腺癌和卵巢癌(BOC) 乳腺癌和卵巢癌(BOC)项目汇集了高度跨学科和协作性的 致力于降低乳腺癌和卵巢癌发病率和死亡率的研究小组。这个 项目促进弗雷德·哈奇(FH)、华盛顿大学(UW)、西雅图癌症的跨学科研究 关怀联盟(SCCA)，并在社区中改进癌症的预防、检测、诊断和 治疗。中国银行项目由Nancy Davidson博士和Elizabeth Swisher博士以及Associate领导 项目负责人，Julie Gralow博士和Barbara Goff博士，他们是上述机构的负责人。 该方案旨在(1)改进评估风险、识别、筛查和预防乳房和卵巢的战略 女性癌症，特别是高危女性；(2)开发针对乳腺癌和卵巢癌的靶向治疗 并特别关注改善反应和预测耐药性。 中国银行项目目前有54名成员，其中11名成员在弗雷德·哈奇大学，43名成员在加州大学 华盛顿。中国银行会员目前的研究支持为1470万美元(直接成本)，其中880万美元为同行研究支持。 审查了资金，包括来自NCI的350万美元。中银计划会员共发表论文628篇 目前的赠款期间，其中20%是方案内赠款，28%是方案间赠款，47%是方案间赠款 外部合著者。所有12家财团共享资源都被中国银行会员在其 工作。这笔P30赠款还通过为中国银行提供行政和后勤支持来协助这一计划 会议，新研究项目的试点资金，以及新教师的招聘资源。

PROJECT SUMMARY: BREAST & OVARY CANCERS (BOC) The Breast & Ovary Cancers (BOC) Program brings together a highly cross-disciplinary and collaborative group of investigators dedicated to reducing the incidence and mortality of breast and ovary cancers. The program fosters interdisciplinary research at Fred Hutch (FH), University of Washington (UW), Seattle Cancer Care Alliance (SCCA), and in the community to improve cancer prevention, detection, diagnosis, and treatment. The BOC Program is led by Drs. Nancy Davidson and Elizabeth Swisher, along with Associate Program Leaders, Drs. Julie Gralow and Barbara Goff, who are leaders at the institutions described above. The Program aims to (1) improve strategies to assess risk, identify, screen, and prevent breast and ovary cancer in women, especially those at high risk and (2) develop targeted therapies for breast and ovary cancers with a special focus on improving response and predicting resistance. The BOC Program currently has 54 members with 11 based at Fred Hutch and 43 based at University of Washington. The current research support of BOC members is $14.7M (direct costs), of which $8.8M is peer- reviewed funding, including $3.5M from the NCI. BOC Program members published a total of 628 papers over the current grant period, of which 20% were intra-programmatic, 28% were inter-programmatic, and 47% had external co-authors. All 12 Consortium Shared Resources were utilized by BOC members in the course of their work. This P30 grant also assists this program by providing administrative and logistical support for BOC meetings, pilot funding for new research projects, and recruitment resources for new faculty.