Research Training in Mood and Anxiety Disorders: From Animal Models to Patients

项目摘要 本申请是为续期T32MH15144资助，“情绪和焦虑症的研究培训： 从动物模型到患者“，该项目自1978年以来一直得到资助。目标是培养博士后(医学博士、 博士和博士)作为独立研究人员的职业生涯。我们的目标的实现程度是以 有多少研究员继续处于研究密集的轨道上，无论是得到K奖还是其他来源的支持 资金的问题。在为期三年的强化计划中，研究员学习识别关键研究问题，制定 假设，并设计和执行测试这些假设的实验。研究员所需的其他技能 要成为一名独立的研究人员，包括了解成功研究的管理 企业、有效协作和写作资助。关于负责任的行为的全面培训 研究在团契早期就开始了。一名研究员必须保持最高标准的科学诚信和 了解与人类和动物研究相关的伦理问题， 培训方案的成功体现在学员的成就和多样性上。 兄弟中的一个。在过去的15年里，48名研究员得到了T32的支持；44%是女性，42%是医学博士，25%是 博士/博士和33%的博士。41%的研究员毕业于哥伦比亚精神病学住院医师计划，59%的人毕业于哥伦比亚精神病学住院医师计划 研究人员来自哥伦比亚以外的地区。13%的研究员是代表不足的少数族裔，27%来自 文化或种族背景不是高加索人，也不是北美或欧洲人。毕业典礼 比率为97%，包括2名6/30/18毕业的现任三年级研究员)(1名未毕业的研究员 在约翰·霍普金斯医学院担任终身教职研究职位一年后离开，并获得了K- 23个奖项)。目前，共有6名研究员：2名三年级研究员、1名二年级研究员和3名一年级研究员；已有2名研究员 接受于2018年7月开始，在过去15年中共有48名研究员得到T32的支持。在42个人中 在过去的15年里，毕业于该项目的学员中，69%获得了K奖项。在21位研究员中， 已经完成了他们的K奖，71%已经获得了R系列奖。在过去的15年中，所有4名少数族裔研究员 所有4个人都获得了K奖(都是医学博士/博士学位--目前有2个城市管理人员正在接受培训)。二 在这些城市管理机构中，也有个别的R01。52%的研究员获得了大量的基金会赠款(20% NARSADS，2美国自杀预防基金会，1罗伯特·伍德·约翰逊)。七个没有这样做的人 获得基础助学金(6个NARSAD，1个AFSP)，因此总共有86%的毕业生获得了 独立资助。在过去15年的42名毕业生中，76%的人从事研究密集型工作， 12%的人从事与研究相关的工作。

Project Summary This application is for renewal of grant T32MH15144, “Research Training in Mood and Anxiety Disorders: From Animal Models to Patients”, that has been funded since 1978. The goal is to train postdoctoral (MD, MD/PhD, and PhD) fellows for careers as independent researchers. Achievement of our goal is measured by how many fellows continue in a research-intensive trajectory whether supported by a K award or other sources of funding. During an intensive three-year program fellows learn to identify key research questions, formulate hypotheses, and design and execute experiments that test those hypotheses. Other skills required for a fellow to become an independent researcher include understanding the administration of a successful research enterprise, effective collaboration and writing grants. Comprehensive training in the Responsible Conduct of Research begins early in the fellowship. A fellow must maintain the highest standards of scientific integrity and understand the ethical issues relevant to human and animal research, The success of the training program is reflected by the accomplishments of the trainees and in the diversity of the fellows. In the past 15 years, 48 fellows have received support from the T32; 44% female, 42% MDs, 25% MD/PhDs and 33% PhDs. 41% of fellows graduated from the Columbia Psychiatric Residency program, 59% of fellows came from outside Columbia. 13% of the fellows are under-represented minorities and 27% come from cultural or ethnic backgrounds that are either not Caucasian or not from North America or Europe. The graduation rate is 97% including the 2 current third year fellows who graduate 6/30/18) (the one fellow who did not graduate left after 1 year for a tenure-track research position at the Johns Hopkins School of Medicine and received a K- 23 award). Currently, there are 6 fellows: 2 third-year, 1 second-year, and 3 first-year; two fellows have been accepted to begin in July 2018, making a total of 48 fellows supported by the T32 in the last 15 years. Of the 42 fellows who graduated the program in the last 15 years, 69% have received K awards. Of the 21 fellows who have finished their K awards, 71% have already received an R series award. All 4 minority fellows in the last 15 years graduated and all 4 received K awards (all were MD/PhDs – there are 2 URMs currently in training). Two of these URMs have also received individual R01s. 52% of fellows received significant foundation grants (20 NARSADs, 2 American Foundation for Suicide Prevention, 1 Robert Wood Johnson). Seven fellows who did not receive a K received a foundation grant (6 NARSADs, 1 AFSP) so in total 86% of graduates have received independent funding. Of the 42 graduates in the past 15 years, 76% are in research-intensive positions and 12% are in research-related positions.