Developing a new aspiration catheter solution for the treatment of large and medium vessel occlusions

项目总结/摘要 中风是导致严重长期残疾的主要原因， 美国的在美国，每年与中风相关的费用总计超过460亿美元。 每年中风的美国人中，87%经历缺血性中风1，其中49%-86%归因于 大血管闭塞（LVO）或中等血管闭塞（MeVO）。2，3机械血栓切除术，通过 支架取栓器或抽吸导管，现在是符合条件的患者的标准治疗， 缺血性中风。4 -6虽然机械血栓切除术在过去几年中取得了显着进展， 现有的抽吸导管装置受到很大的限制。成功治疗的主要挑战 包括快速导航到凝块并在第一次通过时完全捕获它，同时避免 血栓破裂和进一步下游缺血。该项目有两个目标，以解决现有的限制 抽吸血栓切除术第一个目标是开发、构建和测试具有 自适应径向可扩展尖端。该可扩张头端预期用于改善所有患者的临床结局 由于机械血栓切除术改善了入路和导航能力， 首过效应（FPE）。第二个目的是使用体外试验测试新型抽吸导管的功效。 模型该项目将开发一种旨在通过以下方式提高安全性和有效性的器械： 减轻多次通过尝试、凝块破碎和血管损伤。通过这些目标，该项目 通过推动该领域，改善缺血性卒中患者临床结局的潜力 神经介入治疗的发展。

Project Summary/Abstract Stroke is the leading cause of serious long-term disability and accounts for 4.6 million disabled people in the United States. Stroke-related costs total over $46 billion in the United States each year.1 Of the nearly 800,000 Americans who have a stroke per year, 87% experience ischemic stroke1, of which 49%-86% are attributed to either large vessel occlusions (LVO) or medium vessel occlusions (MeVOs).2,3 Mechanical thrombectomy, via a stent retriever or aspiration catheter, is now the standard of care for eligible patients who experience ischemic stroke.4–6 While mechanical thrombectomy has progressed dramatically over the past few years, existing aspiration catheter devices suffer from significant limitations. Major challenges to successful treatment of ischemic stroke include quickly navigating to the clot and fully capturing it in the first pass while avoiding thrombus breakage and further downstream ischemia. This project has two aims to address existing limitations of aspiration thrombectomy. The first aim develops, builds, and tests a prototype aspiration catheter with an adaptive radially expandable tip. This expandable tip is intended to improve clinical outcomes for all patients treated with mechanical thrombectomy due to its improved access and navigation capabilities and enhanced first pass effect (FPE). The second aim tests the efficacy of the novel aspiration catheter using an in vitro model. This project will lead to the development of a device intended to improve safety and efficacy by alleviating multiple pass attempts, clot fragmentation, and vessel injury. Through these goals, this project has the potential to improve the clinical outcome of patients who suffer from ischemic stroke by propelling the field of neuro-interventional treatments forward.