Remediation of Perfluorinated Chemicals in Water Using Novel High-Affinity Polymer Adsorbents

摘要 水供应受到有毒的全氟和多氟烷基物质的污染是一个主要的健康和环境问题 影响当今社会的问题。鉴于这些污染物在环境中的持久性，以及它们已建立的 与严重的健康风险相联系，安全、高效和具有成本效益的全氟辛烷磺酸补救措施势在必行 开发可以从美国供水中消除这些污染物的技术。与 收紧基于健康的污染限制和扩大受监管的全氟辛烷磺酸结构， 据估计，全氟辛烷磺酸污染现在影响了超过2亿美国人。NIEHS赞助的DEXSORB 吸附剂是一种突破性的解决方案，可以安全、快速和经济地去除短和长的 链状全氟辛烷磺酸化合物，包括水中的全氟辛烷磺酸和全氟辛烷磺酸。去除全氟辛烷磺酸需要严格的技术 各国和环境保护局规定的痕量化合物。由可再生的环糊精制成， DEXSORB能够选择性地以痕量浓度的全氟辛烷磺酸化合物为目标，具有快速吸收、高 其处理能力和抗污性使其非常适合用于私人和市政水处理系统。 与环保合作伙伴共同努力，Cyclopure展示了卓越的性能和良好的生活 DEXSORB在水处理试点活动中的循环经济。为了进一步推进具体的里程碑， 完成后将帮助Cyclopure过渡到完全商业化阶段已在此CRP中确定 求婚。Cyclopure在这一计划中的主要目标将是寻求对监管和制造业的支持 援助。在开始全面生产和商业化之前，这两个领域都是至关重要的 活动。将收集和组织与安全和健康相关的信息和相关的实验数据 根据EPA和NSF等监管机构的要求进行材料登记和认证 国际的。在制造援助下的活动将支持开发最优的提纯方法 预计这将在全面制造环境中提供显著的成本和工艺改进。 这项拟议工作的成功完成将使Cyclopure能够过渡到大规模生产和 与行业合作伙伴合作，使DEXSORB可用于为消费者和市政部门提供全氟辛烷磺酸的清除 申请。

Abstract Contamination of water supplies by toxic per- and polyfluoroalkyl substances is a major health and environmental issue impacting society today. Given the environmental persistence of these contaminants and their established linkage to serious health risks, it is imperative that safe, efficient, and cost-effective PFAS remediation technologies be developed that can eliminate these contaminants from the U.S. water supplies. With the tightening of health-based contamination limits and the expansion of regulated PFAS structures, the impacts of PFAS contamination are now estimated to affect over 200 million Americans. NIEHS sponsored DEXSORB adsorbent represents a breakthrough solution for the safe, rapid, and cost-effective removal of short- and long- chain PFAS compounds, including PFOA and PFOS from water. It takes exacting technology to remove PFAS compounds at the trace levels being mandated by States and the EPA. Made from renewable cyclodextrins, DEXSORB’s ability to selectively target PFAS compounds at trace concentrations with rapid uptake, high capacity, and resistance to fouling make it ideally suited for use in private and municipal water treatment systems. Working with environmental partners, Cyclopure has demonstrated the superior performance and favorable life cycle economies of DEXSORB in pilot water treatment activities. To advance further, specific milestones that upon completion will help Cyclopure transition to full commercialization stage have been identified in this CRP proposal. Cyclopure’s main objective in this program will be to seek support for regulatory and manufacturing assistance. Both areas are critical prior to the commencement of full-scale manufacturing and commercialization activities. Safety and health related information and associated experimental data will be collected and organized for material registrations and certifications as required by regulatory agencies including EPA and NSF International. Activities under manufacturing assistance will support developing an optimal purification method that is expected to provide significant cost and process improvements in a full-scale manufacturing environment. Successful completion of this proposed work will enable Cyclopure to transition to large-scale production and work with industry partners to make DEXSORB available to provide PFAS removal for consumer and municipal applications.