UCLA Clinical and Translational Science Institute

总结/摘要 加州大学洛杉矶分校临床和转化科学研究所是加州大学的一个研究伙伴关系 洛杉矶，雪松西奈医疗中心，查尔斯R。德鲁医药科学大学和港口- UCLA医学中心/ Lundquist生物医学创新研究所。我们的使命是将生物医学 创新，以承担最大的健康需求的洛杉矶，一个种族和经济多元化 人口超过一千万的大都会。在过去的10年里，我们建立了强大的研究基础设施， 支持我们的使命在与社区的合作中，我们取得了重要进展， 可预防的残疾和死亡原因。支持这些进步的是精简的监管基础设施。 我们已经建立了科学的审查，减少了42%的时间研究激活，并实现了100%的依从性 随着我们进入下一个十年，我们正在通过扩大 与我们的机构中心合作伙伴的整合，并扩大在社区以及与 卫生专业以外的调查人员。公平、多样性和包容性（EDI）是一个基本的 根据我们的CTSI原则，我们已经开始了一项包容性科学计划，由我们的EDI高级助理领导 主任，以确保我们的研究和培训计划继续遵循这一指导原则。通过 新的T1-T4研讨会和团队科学培训和机会，我们正在装备我们的学员进行 跨翻译谱的多学科团队科学。我们正在系统地评估CTSI 结果和整体影响。加州大学洛杉矶分校CTSI有五个具体目标：1）加强教育和培训， 准备和扩大翻译队伍，2）让利益相关者社区参与多学科 团队科学和传播成功的合作模式，3）整合特殊人群， 包括那些经历健康差距的人，转化研究，4）改进方法， 加快高效、高质量、多地点研究的流程，以及5）提供信息学解决方案 来推进高影响力的转化科学。

SUMMARY/ABSTRACT The UCLA Clinical and Translational Science Institute is a research partnership of the University of California Los Angeles, Cedars-Sinai Medical Center, Charles R. Drew University of Medicine and Science and the Harbor- UCLA Medical Center/ Lundquist Institute for Biomedical Innovation. Our mission is to bring biomedical innovations to bear on the greatest health needs of Los Angeles, an ethnically and economically diverse metropolis of more than 10 million people. In the past 10 years, we have built a robust research infrastructure to support our mission. In partnership with the community, we have made important advances against the leading causes of preventable disability and death. Supporting these advances is a streamlined regulatory infrastructure. We have instituted scientific review, reduced time-to-study-activation by 42%, and achieved 100% compliance with ClinicalTrials.Gov. As we enter our next decade, we are building on our progress by augmenting the integration with our institutional hub partners and broadening collaborations in the community as well as with investigators outside the health professions. Because Equity, Diversity and Inclusion (EDI) is a foundational principle of our CTSI, we have embarked on an Inclusive Science Initiative, led by our EDI Senior Associate Director, to ensure that our research and training programs continue to embrace this guiding principle. Through new T1-T4 seminars and team science trainings and opportunities, we are equipping our trainees to conduct multidisciplinary team science across the translational spectrum. We are systematically evaluating our CTSI outcomes and overall impact. The UCLA CTSI has five specific aims: 1) Enhance education and training to prepare and expand the translational workforce, 2) Engage stakeholder communities in multidisciplinary team science and disseminate successful models of collaboration, 3) Integrate special populations, including those experiencing health disparities, into translational research, 4) Improve methods and processes to accelerate efficient, high-quality, multisite research, and 5) Provide informatics solutions to advance high-impact translational science.