Intellectual and Developmental Disabilities Research Center

项目总结 华盛顿大学尤尼斯·肯尼迪·施莱弗智力与发展 残疾研究中心(IDDRC)，总部设在人类发展中心 和残疾(CHDD)，提供了一个全面的跨学科的基本和 旨在预防、诊断和治疗患者的转化性研究 智力和发育障碍(IDD)。研究是在 以下8个合作研究领域(CRA)的框架：(1)生物学基础 自闭症；(2)脑畸形；(3)中枢神经系统损伤；(4) 儿童早期干预联合会；(5)发育毒理学；(6) 癫痫；(7)听力障碍；(8)学习障碍。所有CRA都是 跨学科，包括科学家、临床医生和实习生，旨在促进 翻译研究。在此应用程序中，为了方便我们的调查人员的工作 IDDRC，我们正在请求支持一个旨在提供 科学和计划领导与四个科学核心：(1)遗传学-- 功能和人类基因组学及模型系统组件；(2)脑成像 人体研究和动物模型的活体成像；(3)动物行为--行为 啮齿动物模型测试和非人灵长类动物模型和咨询 电路标测技术的应用；(4)临床翻译--促进和 支持临床和转化性研究。我们还提议进行一项 研究项目集中在一种独特的小脑畸形上，利用综合- 与核心和国际发展研究中心其他活动很好结合的OMIC方法。 广泛的研究、培训和传播活动也是 我们的国际数据与发展中心。

PROJECT SUMMARY The University of Washington Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center (IDDRC), based at the Center on Human Development and Disability (CHDD), provides a comprehensive interdisciplinary program of basic and translational research designed to prevent, diagnose, and treat individuals with intellectual and developmental disabilities (IDD). Research is carried out within the framework of the following 8 Collaborative Research Areas (CRAs): (1) Biological Basis of Autism; (2) Brain Malformation Disorders; (3) Central Nervous System Injury; (4) Consortium on Early Childhood Intervention; (5) Developmental Toxicology; (6) Epilepsy; (7) Hearing Disorders, and (8) Learning Disabilities. All CRAs are interdisciplinary, include scientists, clinicians, and trainees and are designed to promote translational research. In this application, to facilitate the work of investigators at our IDDRC, we are requesting support for an Administrative Core designed to provide scientific and programmatic leadership and four scientific cores: (1) Genetics -- functional and human genomics and model system components; (2) Brain Imaging -- in vivo imaging for human studies and animal models; (3) Animal Behavior -- behavioral testing for rodent models and consultation for non-human primate models and application of circuit mapping techniques; and (4) Clinical Translational -- promotes and supports clinical and translational research. We are also proposing to conduct a research project focusing on a unique cerebellar malformation utilizing comprehensive- omic approaches that are well integrated with cores and other IDDRC activities. Extensive research training and dissemination activities are also integral components of our IDDRC.